Project description
Smart components and smart systems integration
A spearhead function that lies within the promise of MNBS technologies is the rapid and sensitive detection of biomarker molecules in raw biological samples. However, it has been very difficult to realize the promise due to two key challenges:the signal-over-background challenge, i.e. many biomarkers have very low concentrations and real-life biological samples generate very high background signals, andthe integration challenge, i.e. it is very difficult to conceive a system that has a very high performance and is still fully integrated, miniaturized, and cost-effective.NextDx will address these challenges by investigating an integrated system for protein biomarker detection with single molecule resolution. The system is based on magnetic nanoparticles that are controlled by electromagnetic fields and detected with nanometer precision in an integrated optical chip with bio-engineered surface. The system will allow a sharp biophysical discrimination between biomarker-induced and non-biomarker-induced nanoparticle binding signals, so as to approach the fundamental limit of counting statistics in real biological samples. This is a unique, novel, and timely approach.At the end of NextDx, we will demonstrate an integrated MNBS platform technology for extremely sensitive protein detection, within a few minutes, directly in blood plasma. The technology will be suitable for multiple biomarker testing outside the hospital, to improve for example the lives of chronically ill patients.NextDx is a unique international consortium with best-in-class partners contributing complementary physical and biomolecular engineering expertise, supported by an advisory board with all relevant stakeholders (clinicians, patient organisation, insurance company, regulatory agency). Together, all are focused on generating new insights in MNBS integration and on effective industrial-academic collaboration on the European scale towards next-generation integrated diagnostics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences physical sciences electromagnetism and electronics electromagnetism
- natural sciences biological sciences biochemistry biomolecules proteins
- social sciences sociology social issues social inequalities
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-ICT-2011-8
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
5656 AG Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.