Dynamic Constitutional Chemistry for the Preparation of Receptors for Anions of Biological Interest

Objectif

From chloride to DNA, over 75% of the cofactors and bio-molecules have negative charge at physiological pH. However, efficient synthetic
receptors for anionic entities in aqueous solution have attracted lesser attention than ligands for cationic or neutral species. The intrinsic
physicochemical problems of anion binding and the molecular diversity of anionic species have often hampered this research field. In this project,
the identification and synthesis of new molecular receptors for anions with biological relevance is proposed. To this aim, we will use a
constitutional dynamic chemistry approach, a conceptually new methodology based on the molecular evolution idea. Thus, we will prepare a
dynamic library of components interconnected through exchange by chemical equilibriums. These building blocks will bear a molecular recognition
moiety able to bind anions, and the required functional group(s) for the establishment of a covalent bond under reversible conditions. In the
presence of the target entity (an anionic template), the dynamic system will evolve to efficiently interact with the template and the best binder will
be amplified and identified. As the building blocks, we will use peptide-like molecular architectures, since they can bear different potential anion
binding functions (amide, ammonium, etc…), show large molecular and structural diversity and, in general, display good biological tolerance.
Additionally, their synthetic, isolation and characterization procedures are quite straightforward. Using this rationale with anionic templates of
biological importance, this methodology will allow us to synthesize new receptors of biologically interesting molecules with increased binding
abilities, which will be finally tested for the corresponding biological functions. Therefore, if successful, this project will mean an important
methodological breakthrough in anion recognition chemistry.

Champ scientifique

Coordinateur

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS

Contribution de l’UE

€ 100 000,00

Adresse

CALLE SERRANO 117
28006 Madrid
Espagne

Région

Comunidad de Madrid Comunidad de Madrid Madrid

Type d’activité

Research Organisations

Contact administratif

Alberto Sereno Alvarez (Mr.)

Liens

Contacter l’organisation Site web

Coût total

Aucune donnée

Objectif

Champ scientifique

Programme(s)

Thème(s)

Appel à propositions

Régime de financement

Coordinateur

Partager cette page

Télécharger