Objective EURenOmics will integrate several established consortia devoted to rare kidney diseases with eminent need and potential for diagnostic and therapeutic progress (i.e. steroid resistant nephrotic syndrome, membranous nephropathy, tubulopathies, complement disorders such a haemolytic uraemic syndrome, and congenital kidney malformations). The Consortium has access to the largest clinical cohorts assembled to date (collectively >10,000 patients) with detailed phenotypic information and comprehensive biorepositories containing DNA, blood, urine, amniotic fluid and kidney tissue. The project aims to (1) identify the genetic and epigenetic causes and modifiers of disease and their molecular pathways; (2) define a novel mechanistic disease ontology beyond phenotypical or morphological description; (3) develop innovative technologies allowing rapid diagnostic testing; (4) discover and validate biomarkers of disease activity, prognosis and treatment responses; and (5) develop in vitro and in vivo disease models and apply high-throughput compound library screening. For these purposes we will integrate comprehensive data sets from next generation exome and whole-genome sequencing, ChiP-sequencing, tissue transcriptome and antigen/epitope profiling, and miRNome, proteome/peptidome, and metabolome screening in different body fluids within and across conventional diagnostic categories. These data will be combined in a systems biology approach with high-resolution clinical phenotyping and findings obtained with a large array of established and novel in vitro, ex vivo and in vivo disease models (‘functiomics’) to identify disease-associated genetic variants involved in monogenic or complex genetic transmission, disease-defining molecular signatures, and potential targets for therapeutic intervention. These efforts will converge in the development of innovative diagnostic tools and biomarkers and efficient screening strategies for novel therapeutic agents. Fields of science natural sciencescomputer and information sciencesknowledge engineeringontologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicinenephrologykidney diseases Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.2.1.1-1-B - Clinical utility of -omics for better diagnosis of rare diseases Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSITATSKLINIKUM HEIDELBERG EU contribution € 973 178,18 Address IM NEUENHEIMER FELD 672 69120 Heidelberg Germany See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Thorsten Brietz (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (28) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 1 845 713,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nicolas Jeanjean (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAT ZURICH Switzerland EU contribution € 584 788,00 Address RAMISTRASSE 71 8006 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Olivier Devuyst (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Italy EU contribution € 650 001,00 Address VIA MARIO NEGRI 2 20156 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Research Organisations Administrative Contact Maria Grazia Pezzoni (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 474 910,00 Address HEIDELBERGLAAN 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Joost Warsanis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF MICHIGAN THE REGENTS OF THE UNIVERSITY OF MICHIGAN United States EU contribution € 418 198,00 Address SOUTH STREET 3003 1068 46109 1274 Ann Arbor See on map Activity type Higher or Secondary Education Establishments Administrative Contact Christine Koch (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HACETTEPE UNIVERSITESI Türkiye EU contribution € 375 000,00 Address HACETTEPE UNIVERSITESI BEYTEPE KAMPUSU REKTORLUK BINASI 06800 Cankaya Ankara See on map Region Batı Anadolu Ankara Ankara Activity type Higher or Secondary Education Establishments Administrative Contact Fatih Ozaltin (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF BRISTOL United Kingdom EU contribution € 249 517,00 Address BEACON HOUSE QUEENS ROAD BS8 1QU Bristol See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Activity type Higher or Secondary Education Establishments Administrative Contact Elodie Mahieu-Wedande (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 521 691,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Wim Van Oijen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 249 883,00 Address OXFORD ROAD M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Katherine Boylan (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution € 374 156,00 Address GOWER STREET WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Borg-Carbott Greta (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 240 000,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Alberto Sereno Alvarez (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF NEWCASTLE UPON TYNE United Kingdom EU contribution € 149 592,00 Address KINGS GATE NE1 7RU Newcastle Upon Tyne See on map Region North East (England) Northumberland and Tyne and Wear Tyneside Activity type Higher or Secondary Education Establishments Administrative Contact Aleona Blinova (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 149 640,00 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Alix Pillot (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-INSTITUT Germany EU contribution € 150 000,00 Address BEUTENBERG STRASSE 11A 07745 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Michael Ramm (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 49 998,00 Address OUDE MARKT 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Sarah Malevé (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data OULUN YLIOPISTO Finland EU contribution € 234 900,00 Address PENTTI KAITERAN KATU 1 90014 Oulu See on map Region Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa Activity type Higher or Secondary Education Establishments Administrative Contact Arto Eljander (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Genomatix Software GmbH Germany EU contribution € 957 000,00 Address Bayerstrasse 85a 80335 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Administrative Contact Korbinian Grote (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data METABOMETRIX LTD United Kingdom EU contribution € 487 000,00 Address PRINCE CONSORT ROAD SW7 2BP LONDON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact John Lindon (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MULTIPLICOM NV Belgium EU contribution € 351 600,00 Address GALILEILAAN 18 2845 NIEL See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Luc Lammens (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PHILOGEN SPA Italy EU contribution € 149 960,00 Address PIAZZA LA LIZZA 7 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Chiara Falciani (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PHILOCHEM AG Switzerland EU contribution € 440 000,00 Address LIBERNSTRASSE 3 8112 Otelfingen See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Sarah Wulhfard (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HUMMINGBIRD DIAGNOSTICS GMBH Germany EU contribution € 390 000,00 Address IM NEUENHEIMER FELD 583 69120 HEIDELBERG See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Markus Beier (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MOSAIQUES DIAGNOSTICS GMBH Germany EU contribution € 345 000,00 Address ROTENBURGER STRASSE 20 30659 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Petra Zürbig (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Participation ended Germany EU contribution € 214 407,82 Address OSKAR VON MILLER RING 29 80333 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Birgit Fuchs (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KARLSRUHER INSTITUT FUER TECHNOLOGIE Participation ended Germany EU contribution € 2 653,50 Address KAISERSTRASSE 12 76131 Karlsruhe See on map Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Natascha Kindsvogel (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution € 516 052,00 Address GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact André Brändli (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACQUIFER AG Germany EU contribution € 280 000,50 Address FREIBURGER STRASSE 1-3 75179 Pforzheim See on map Region Baden-Württemberg Karlsruhe Pforzheim, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ralf Mulflur Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CMAST Belgium EU contribution € 169 728,00 Address GEORGES VAN DAMMEPLEIN 57 9140 TEMSE See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Sint-Niklaas Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Karin Van Den Eeden (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
