Objective
Metazoans establish reciprocal interactions with the bacterial communities that colonize their mucosal surfaces. These interactions contribute to many aspects of host physiology including the promotion of digestive efficiency and proper immune system development and homeostasis. In return, the microbiota derives benefit from the association with its host by inhabiting a nutrient rich environment. When deregulated this relationship results in pathological outcomes such as episodic infectious diseases, chronic inflammatory diseases, metabolic disorders or even some cancers. Despite recent progress, a clear view of the physiological benefits associated with host/microbiota relationship remains elusive. Hence the molecular mechanisms through which the microbiota exerts its beneficial influences are still largely undefined.
The goal of this research proposal is to decipher the molecular dialogue governing the mutualistic interaction between intestinal bacteria and their host. To this end, we will use an animal model, Drosophila melanogaster and one of its natural commensals, Lactobacillus plantarum. We aim to develop a multiscale functional approach to study the molecular mechanisms underlying their mutualistic association. This integrated approach will couple a host and a bacteria centred-view of this beneficial interaction to identify, the bacterial and host genetic networks required to sustain a mutualistic relationship. We will reveal how these molecular activities translate into cellular, tissular and organismal functional benefits and will uncover the interdependency of these benefits. Using a model lactic acid bacteria species and an animal host model with evolutionary conserved molecular and physiological features, our approach is relevant to most lactobacilli/host interactions including those occurring in humans. This project will provide fresh and unbiased insight into the fundamental biological question of host/microbe mutualism.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-StG_20111109
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.