Objective
The canonical Wnt pathway plays a central role in stem cell maintenance, differentiation and proliferation in the adult, self-renewing intestinal epithelium. Wnt signaling activates gene expression through the induced formation of complexes between DNA-binding TCF factors and the transcriptional co-activator β-catenin. Constitutive, aberrant transcriptional activity of the TCF4/β-catenin complex, caused by mutations in APC, AXIN or β-catenin, is the primary transforming factor in colorectal cancer. At present, despite great inroads into the processes involved in Wnt-dependent transcriptional regulation, the mechanisms by which TCF4/β-catenin regulate target genes remain incompletely understood. My post-doctoral research on these mechanisms uncovered tantalizing clues for the existence of previously unappreciated layers in the Wnt-dependent repertoire of transcriptional targets and mediators. These clues point to the existence of long intergenic non-coding RNAs (lincRNAs), the expression of which is regulated by the Wnt pathway and which, in turn, mediate its transcriptional activity and output. The proposed work aims at i) the systematic identification of such Wnt-regulated lincRNAs ii) the discovery of the protein factors with which they interact and iii) the elucidation of their functional and mechanistic contribution to Wnt-dependent transcription. These studies promise to shed light on new players and principles involved in normal and abnormal intestine physiology and to generate novel therapeutic targets in colorectal cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology colorectal cancer
- natural sciences biological sciences genetics mutation
- medical and health sciences basic medicine physiology
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
16 672 VARI-ATHENS
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.