Objective
Alzheimer's disease (AD) is the most common form of age-related dementia. This neurodegenerative disorder is characterized by massive neuronal death and deposition of amyloid-β peptide (Aβ), which is formed by processing of amyloid precursor protein (APP). The mechanism of neuronal degeneration in AD are not well understood, but growing evidence shown that neuronal death is at least in part due to dysregulated Ca2+ signalling.
Calsenilin/DREAM was identified as a Ca2+-binding protein that interacts with presenilins, serves as a transcription repressor, and binds to the A-type potassium channel. Ca2+-insensitive DREAM mutants or DREAM mutants with an altered capability to regulate transcription will modify Ca2+ homeostasis and synaptic plasticity. Previous findings suggest that DREAM/calsenilin is involved in apoptosis and Aβ production. However, high levels of DREAM/calsenilin were found in the cortex of AD brains and in the neocortex and the hippocampus of Swedish mutant APP (APPswe) transgenic mice brains.
The general objective of the project is to elucidate the role of DREAM/calsenilin on the progression of synaptic dysfunction. The specific objectives for the project are:
-To study of DREAM and DREAM mutants in regards to AD-related markers of AD.
-Analysis of DREAM expression in brains from different transgenic models of AD.
-To assess the functional consequences of mutant DREAM overexpression in the development of AD in animal models overexpressing mutant human APP
-Effect of DREAM deletion in the development of AD.
-Integration of the information obtained in post-mortem material from AD patients.
-To screen molecules able of interacting with DREAM for their potential therapeutic effect.
As a result of this study, the synaptic dysfunction associated to neurodegenerative processes may be modified, suggesting potential new targets for human drug development based on DREAM function.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences basic medicine neurology dementia alzheimer
- natural sciences chemical sciences inorganic chemistry alkali metals
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.