Project description Smart components and smart systems integration Show the project objective Hide the project objective This project will develop a family of In-Vitro Diagnostic Systems that will transfer for the first time novel Non Invasive Prenatal Diagnostic (NIPD) methods in tube to a LabonaChip format. This family will consist of three research systems chosen to cover all prenatal diagnosis models:- ANGELAB1. This system will use a LabonaChip to extract fetal DNA from the mother´s plasma based on differences in methylated pattern between fetus and mother and captured by specific magnetophoresis, plus qPCR for monogenic diseases with a known mutation for: Spinal Muscular Atrophy, Cystic Fibrosis (CF), and X-linked disorders. It will be used only for high risk population.- ANGELAB2. It will use a LabonaChip to carry out immunoprecipitation (MeDIP) for fetal DNA extraction from mother´s blood and real time quantitative Polymerase Chain Reaction (real time qPCR) for Aneuploidies of chromosomes 13, 18, 21, X and Y. It will be used for population screening purposes.- ANGELAB3. This system will use the DNA sample provided from ANGELAB1 or ANGELAB2 and it will carry out Digital PCR on a LabonaChip to detect: CF (unknown multiple mutations), b-thalassemia and achondroplasia. I will be used for population screening purposes.All systems can manage 8 samples at a time. They can be modularly assembled to themselves, offering a system adaptable to different throughput needs.The consortium will also develop and integrate a LabonaChip Pilot Production Line (LPPL):- LPPL: This pilot line setup will provide a sustainable and economic LabonChip manufacturing. Materials, processes, and their life cycle will be considered. The environmental assessment will be carried out following ISO 14044. Quality control tools will be integrated along the entire production chain of LabonaChips.This project will end with the implementation of these three diagnostic systems as pilot routines in two Hospitals through a technical validation of 700 pregnancies. Fields of science natural sciencesbiological sciencesgeneticsDNAengineering and technologyother engineering and technologiesmicrotechnologylab on a chipmedical and health sciencesclinical medicineobstetricsfetal medicinenatural sciencesbiological sciencesgeneticsmutationmedical and health sciencesclinical medicineembryology Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2011.3.2 - Smart components and smart systems integration Call for proposal FP7-ICT-2011-8 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator IKERLAN S. COOP EU contribution € 1 916 754,00 Address P JOSE MARIA ARIZMENDIARRIETA 2 20500 Mondragon Spain See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Administrative Contact Chris Merveille (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all EV GROUP E. THALLNER GMBH Austria EU contribution € 392 785,00 Address DI ERICH THALLNER STRASSE 1 4782 St Florian Am Inn See on map Region Westösterreich Oberösterreich Innviertel Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Werner Thallner (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KYPRIAKO IDRYMA EREVNON GIA TI MYIKI DISTROFIA Cyprus EU contribution € 641 315,00 Address 6 IROON AVENUE 2371 AGIOS DOMETIOS See on map Region Κύπρος Κύπρος Κύπρος Activity type Research Organisations Administrative Contact Marios Flouros (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NIPD GENETICS PUBLIC COMPANY LIMITED Cyprus EU contribution € 729 281,00 Address NEAS EGKOMIS, 31 2409 NICOSIA See on map Region Κύπρος Κύπρος Κύπρος Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Costas Anastassiades (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Centrum fur Angewandte Nanotechnologie (CAN) GmbH Germany EU contribution € 1 017 992,00 Address Grindelallee 117 20146 Hamburg See on map Activity type Research Organisations Administrative Contact Anja Hansel Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HAHN-SCHICKARD-GESELLSCHAFT FUR ANGEWANDTE FORSCHUNG EV Germany EU contribution € 710 646,00 Address WILHELM SCHICKARD STRASSE 10 78052 Villingen Schwenning See on map Region Baden-Württemberg Freiburg Schwarzwald-Baar-Kreis Activity type Research Organisations Administrative Contact Saskia Becker Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Servicio Vasco de Salud Osakidetza Spain EU contribution € 395 649,00 Address Alava 45 01006 Vitoria-Gasteiz See on map Region Noreste País Vasco Araba/Álava Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Idoia Minguez (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASOCIACION INSTITUTO DE INVESTIGACION SANITARIA BIOGIPUZKOA Spain EU contribution € 136 403,00 Address PASEO DR BEGUIRISTAIN SN 20014 DONOSTIA-SAN SEBASTIAN See on map Region Noreste País Vasco Gipuzkoa Activity type Research Organisations Administrative Contact Alaitz Zabala (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data POC MICROSOLUTIONS SL Participation ended Spain EU contribution € 99 755,00 Address GOIRU 9 20500 MONDRAGON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact MARCIN PACEK (Dr.) Links Contact the organisation Opens in new window Total cost No data DNA DATA SLP Spain EU contribution € 279 004,00 Address PASEO MIRAMON 174 20014 SAN SEBASTIAN GUIPUZCOA See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Concha Vidales (Dr.) Links Contact the organisation Opens in new window Total cost No data FUNDACION GAIKER Spain EU contribution € 217 523,00 Address PARQUE TECNOLOGICO DE VIZCAYA, EDIFICIO 202 48170 Zamudio See on map Region Noreste País Vasco Bizkaia Activity type Research Organisations Administrative Contact Silvia Arriaga (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION RIOJA SALUD-FRS Spain EU contribution € 908 384,00 Address CALLE PIQUERAS 98 26006 Logrono See on map Region Noreste La Rioja La Rioja Activity type Research Organisations Administrative Contact Jose Maria Corcuera Briones (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ADEMTECH SA France EU contribution € 290 326,00 Address ALLEE CHARLES DARWIN 27 BAT C BIOPARC BIOGALIEN 33600 PESSAC See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bernard Plichon Links Contact the organisation Opens in new window Total cost No data POLITECHNIKA WROCLAWSKA Poland EU contribution € 142 648,00 Address WYBRZEZE WYSPIANSKIEGO 27 50-370 Wroclaw See on map Region Makroregion południowo-zachodni Dolnośląskie Miasto Wrocław Activity type Higher or Secondary Education Establishments Administrative Contact Kubicz Bożena (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOPHARMA TECHNOLOGY LTD United Kingdom EU contribution € 87 220,00 Address WINNALL VALLEY ROAD 9 SO23 0LD WINCHESTER See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Kevin Ward (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION VASCA DE INNOVACION E INVESTIGACION SANITARIAS Spain EU contribution € 300 253,00 Address RONDA DE AZKUE,1 48902 Barakaldo See on map Region Noreste País Vasco Bizkaia Activity type Research Organisations Administrative Contact Idoia Minguez (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data