Objectif This ERC proposal aims to bridge the gap between supramolecular chemistry and regenerative medicine by defining a new area of ‘supramolecular medicine’ in which supramolecular chemistry will be used to solve medical and health problems. Understanding of tissues, cells, and the interactions occurring at the molecular level in natural systems is prerequisite to intervene in and stimulate processes in the body, in order to perform regenerative medicine. Because all processes taking place in our body are based on supramolecular interactions between molecules that are dynamic in nature and have certain on-off rates, we anticipate that biomaterials brought into the body should display this same dynamic behaviour, and should be able to adapt to the tissue they encounter. Therefore, in the field of regenerative medicine there is a need for new biomaterials that are supramolecular in nature and are indistinguishable from their natural counterparts.Here we describe the design of supramolecular biomaterials that can be applied as synthetic extracellular matrices and synthetic cell-like microcapsules. By designing these synthetic systems as indistinguishably from nature we propose to get more insight in the processes occurring in nature. At a fundamental molecular level several molecules will be brought together to form bioactive complex molecular assemblies. Control over the introduction of bioactivity is necessary for selective interactions with specific cells and (parts of) tissues. These design principles will be applied to make different biomaterials that can be brought to the patient as synthetic extracellular matrix gel-like materials for stem cell incorporation, free-standing membranes for the development of bioartificial kidneys, and microcapsules specifically binding to the deteriorating peritoneal membranes of kidney patients on peritoneal dialysis. Champ scientifique medical and health sciencesmedical biotechnologycells technologiesstem cellsengineering and technologyindustrial biotechnologybiomaterialsmedical and health sciencesclinical medicinenephrologyrenal dialysis Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Appel à propositions ERC-2012-StG_20111012 Voir d’autres projets de cet appel Régime de financement ERC-SG - ERC Starting Grant Institution d’accueil TECHNISCHE UNIVERSITEIT EINDHOVEN Contribution de l’UE € 1 351 744,00 Adresse GROENE LOPER 3 5612 AE Eindhoven Pays-Bas Voir sur la carte Région Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Type d’activité Higher or Secondary Education Establishments Contact administratif Sagitta Peters (Mrs.) Chercheur principal Patricia Yvonne Wilhelmina Dankers (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire TECHNISCHE UNIVERSITEIT EINDHOVEN Pays-Bas Contribution de l’UE € 1 351 744,00 Adresse GROENE LOPER 3 5612 AE Eindhoven Voir sur la carte Région Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Type d’activité Higher or Secondary Education Establishments Contact administratif Sagitta Peters (Mrs.) Chercheur principal Patricia Yvonne Wilhelmina Dankers (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
