Objective
Silicone offers significant advantages as a 3D cell scaffold, essentially a 3D microtissue device. These benefits include a capacity for variable porosity, variable open pore volume for cell entrapment, variable density for fluidisation, variable geometry, friction resistance, and low toxicity. The lead SME partner Cellon SA holds the IP for porous silicone carriers (Immobasil), which met some of these criteria, but exhibited poor cell adherence and requires re-engineering and exploitation of current cell biology knowledge and applications. There is a strong commercial need for such fully functional 3D cell culture technologies (microtissue) that can be manufactured into robust and reproducible in vitro test systems for toxicity testing, drug testing, cosmetic testing as part of a projected €1.6b cell based test market.
This technology developed maybe suitable as an active component in bioartificial livers (BAL) and other bioartificial organ devices. The market growth is driven by needs in drug screening for drug discovery and toxicity screening. There are also a number of current EU directives that is driving the demand for reliable in vitro 3D cell based test system to replace in vivo test systems. The bio artificial liver market is also expected to grow rapidly due to high rates of liver disease worldwide.
The objectives will be to deliver:
1) Immortalised hepatocyte and endothelial cells that retain characteristics of primary liver cells in 3D co-culture.
2) An improved porous silicone carrier for 3D culture of these cells (cell-carrier component)
3) A prototype fluidized bioreactor bed for culture of these cell carrier components.
4) Cell carrier component tested in a microwell plate
The results of this project could form the basis for subsequent (following the completion of the SpeCCC project) commercial development as follows 1) 3D liver cell multiwell plate assay system, 2) 3D liver microbioreactor system and 3) a bioreactor component for a BAL device. Minimal SME economic return is predicted at €12m within 3 years of project completion.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- engineering and technology environmental biotechnology bioremediation bioreactors
- medical and health sciences clinical medicine hepatology
- medical and health sciences medical biotechnology tissue engineering bioartificial liver
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-SME-2012
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
4940 BASCHARAGE
Luxembourg
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.