Objective
The requirements on the eukaryotic cytoskeleton are not only of high complexity, but include demands that are actually contradictory in the first place: While the dynamic character of cytoskeletal structures is essential for the motility of cells, their ability for morphological reorganisations and cell division, the structural integrity of cells relies on the stability of cytoskeletal structures. From a biophysical point of view, this dynamic structure formation and stabilization stems from a self-organisation process that is tightly controlled by the simultaneous and competing function of a plethora of actin binding proteins (ABPs). The ABPs can be classified to regulate (1) the polymerisation and depolymerisation kinetics of the individual filaments, (2) the structure of the network by crosslinking and bundling the filaments and (3) the dynamic reorganisation and contraction mediated by molecular motors.
The major goal is to obtain a sound physical understanding of cellular self organizing principles, by successively increase the complexity of the experimental system in a bottom up approach. Three work packages are defined: (i) the microscopic mechanism of the interaction of ABPs with actin filaments on the treadmilling behaviour of actin. (ii) the effect of confinement, hydrodynamic flow and crosslinking proteins in a 2D high density motility assay and (iii) developing a reconstituted 3D active gel composed of actin filaments and crosslinking molecules. To this end, we will introduce and combine established and new biophysical and biochemical methods and interdisciplinary approaches, with a major emphasis on quantitative imaging and analysis techniques. The outcome of the proposed research will have important consequences and impact in fields ranging way beyond biophysics. Direct implications in rheology, polymer physics, material sciences and cell biology are evident, but also new aspects for the construction of novel biomaterials can be expected.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- natural sciences chemical sciences polymer sciences
- natural sciences biological sciences biophysics
- engineering and technology industrial biotechnology biomaterials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-ADG_20110209
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
80333 Muenchen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.