Objective
Pathogens exploit cellular resources for their own benefit and their propagation. Co-evolution of viruses and their hosts led to the establishment of very specific interactions between both partners. The balance between both, the viral attack and the cellular defense mechanisms, dictates the outcome of an infection, either leading to a cure, to disease or life-long co-existence. Efforts from many laboratories have focused on virus-host interactions, mostly by testing isolated protein-protein interactions or by employing transcriptome analysis. Although this undoubtedly has been highly valuable to our knowledge on virus-host interactions, it is also clear that most virus-host interactions do not occur on transcriptome level and neither involve single protein-protein interactions. Here I propose to systematically test the impact of virus infection on the host proteome (iViP) by using the newest generation of mass spectrometry-based discovery tools combined with infection biology. iViP divides in three interconnected parts that individually and collectively warrant success: Part I evaluates changes in the abundance of the proteins after virus infection and correlates this to mRNA levels, determined by RNA sequencing. Part II identifies proteome-wide post-translational modifications that would be indicative for an involvement in infection biology. Part III dissects the role of virus stimulated/altered proteins in the antiviral protein-protein interaction network. Lastly, identified proteins will be validated in a two –step procedure involving a large-scale validation strategy and further focusing on few selected interactors. A comprehensive coherent data set describing and functionally explaining the cellular changes after encounter of a variety of viral pathogens on a proteome level would complement or even succeed currently available data sets and become invaluable to basic and translational research of the future.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences genetics RNA
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-StG_20111109
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.