Objective METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ageing populations and costly treatments. Therapies require novel integrated approaches taking into account CMD natural evolution.METACARDIS associates European leaders in metagenomics, who have been successful in establishing the structure of the human microbiome as part of the EU FP7 MetaHIT consortium, clinical and fundamental researchers, SME, patients associations and food companies to improve the understanding of pathophysiological mechanisms, prognosis and diagnosis of CMD.We will use next-generation sequencing technologies and high throughput metabolomic platforms to identify gut microbiota- and metabolomic-derived biomarkers and targets associated with CMD risks. The pathophysiological role of these markers will be tested in both preclinical models and replication cohorts allowing the study of CMD progression in patients collected in three European clinical centres of excellence. Their impact on host gene transcription will be characterised in patients selected for typical features of CMD evolution. Application of computational models and visualisation tools to complex datasets combining clinical information, environmental patterns and gut microbiome, metabolome and transcriptome data is a central integrating component in the research, which will be driven by world leaders in metagenomic and functional genomic data analysis. These studies will identify novel molecular targets, biomarkers and predictors of CMD progression, paving the way for personalized medicine in CMD. Fields of science medical and health sciencesclinical medicineendocrinologydiabetesmedical and health scienceshealth sciencespersonalized medicinenatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesmicrobiologymedical and health scienceshealth sciencesnutritionobesity Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.2.1.2-2 - Systems medicine: Applying systems biology approaches for understanding multifactorial human diseases and their co-morbidities Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE EU contribution € 2 562 788,00 Address RUE DE TOLBIAC 101 75654 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Akouavi Ekoue (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (15) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT France EU contribution € 2 649 374,00 Address 147 RUE DE L'UNIVERSITE 75007 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Lucie Bourse (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 1 151 649,80 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KOBENHAVNS UNIVERSITET Denmark EU contribution € 865 050,00 Address NORREGADE 10 1165 Kobenhavn See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Kristoffersen Ivan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution € 911 396,00 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Phil Irving (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GOETEBORGS UNIVERSITET Sweden EU contribution € 649 999,00 Address VASAPARKEN 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Ellen Rydberg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VIB VZW Belgium EU contribution € 586 590,00 Address SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT See on map Region Vlaams Gewest Prov. 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Gent Activity type Research Organisations Administrative Contact Rik Audenaert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 540 000,00 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Alix Pillot (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET LEIPZIG Germany EU contribution € 715 480,00 Address RITTERSTRASSE 26 04109 Leipzig See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Administrative Contact Michael Stumvoll (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DANONE RESEARCH SAS France EU contribution € 159 400,00 Address ROUTE DEPARTEMENTALE 128 91767 Palaiseau See on map Region Ile-de-France Ile-de-France Essonne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nicolas Gausseres (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CARGILL HAUBOURDIN SAS Participation ended France EU contribution € 19 000,00 Address RUE DU MARECHAL JOFFRE 7 59482 HAUBOURDIN See on map Region Hauts-de-France Nord-Pas de Calais Nord Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Douwina Bosscher (Dr.) Links Contact the organisation Opens in new window Total cost No data CHALMERS TEKNISKA HOGSKOLA AB Sweden EU contribution € 550 000,00 Address - 412 96 GOTEBORG See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Karin Ryrberg (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSERM TRANSFERT SA France EU contribution € 496 328,00 Address 10 RUE D'ORADOUR-SUR-GLANE - PARISANTE CAMPUS 75015 PARIS See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Catherine Clusel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOBYTE SOLUTIONS GMBH Germany EU contribution € 142 937,20 Address Bothestrasse 142 69126 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ivica Letunic (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDATION CARDIOMETABOLISME NUTRITION France EU contribution No data Address BOULEVARD DE L'HOPITAL 47-83 75013 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Marie-Laure Henrotte (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CARGILL R&D CENTRE EUROPE Belgium EU contribution No data Address HAVENSTRAAT 84 1800 Vilvoorde See on map Region Vlaams Gewest Prov. 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