Objective
Balanced energy homeostasis and correct functioning of regulatory processes are the basis of cellular health. The impaired interplay between these is thus responsible for the pathology of tissues especially for those undergoing stress and unable to regenerate such as the Brain. An exhaustive comprehension of the physiology of molecules intimately involved in these phenomena is therefore essential both to increase our understanding of Brain fundamental physiology and to delineate novel approaches to tackle pathologies at their origin. The mitochondrial Translocator Protein (mTSPO) is one of these molecules as critically located on the outer membrane of the mitochondrion and in close association with the multi-functional protein Voltage Dependent Anion Channel (VDAC). mTSPO is increases during brain inflammation but, in spite of this, its cell biology and the underlying events associated to changes in its expression are still obscure.
The research program I propose here aims to elucidate this pathway for mitochondrial and cellular physiology and so finalize an understating on a neglected molecule upon which the homeostasis of the cell dependents.
We will address the mTSPO role in mitochondrial and cell metabolism and to the processes guarding cell integrity such as Apoptosis and Autophagy; we will do so by ascertaining how mTSPO ratio of expression with that of VDAC defines the signalling of Ca2+, dynamics of the Reactive Oxygen Species (ROS), ATP rationing and Redox State. How modifications in ROS impinge on downstream kinases will be also determined. Pharmacological tools to modulate mTSPO activity will be employed as a further means of investigation and finally the relation between mTSPO/VDAC ratio of expression and pathological behaviour of tissues will be scrutinized.
These results will shed light on an important molecular player and form a conceptual and experimental framework for future investigations in the Physio-Pathology of the Brain.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology cell metabolism
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology homeostasis
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
00133 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.