Objective The goals of MEMTRANS project are to optimize and pre-validate in vitro cultured cell models to predict oral absorption and pharmacokinetics of efflux systems substrates (P-gp, MRP2, BCRX for instance), to establish an in vitro cut off for the risk of secretion associated problems and to study the structure-affinity-transport relationships. That would allow:1) A reduction in the number of animal experiments to study efflux processes;2) The in vitro study of drug-drug (including phytopharmaca), drug-food, interactions related with secretion transporters;3) To obtain useful information for modelling transporter interactions in other normal and transformed tissues (blood brain barrier, lung mucosa, tumours).The objectives of the project will be achieved by using a systems biology approach that involves modelling and simulating the complex dynamic interactions between proteins (transporters), metabolites (i.e substrates) and cells (lipoidal barriers). Computational and mathematical predictive models will be generated from the data based on the system parameters and in the drug characteristics. The experimental data generated in the project will be analysed from a mechanistical point of view in order to split all the individual steps involved in transport. The mathematical models in combination with the right physiological, physicochemical and chemical information could be applied to predict drug transport in a wide range of membranes in the organism (blood brain barrier, liver, kidney, tumours etc.) but especially in the gastrointestinal tract. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmacokineticsnatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2004-1.2.3-2 - Optimization and pre-validation of in-vitro models for the study of drug absorption, modification and detoxification in the liver and in the intestinal epithelium (especially orientated towards involve Call for proposal FP6-2004-LIFESCIHEALTH-5 See other projects for this call Funding Scheme IP - Integrated Project Coordinator UNIVERSITAT DE VALÈNCIA. ESTUDI GENERAL EU contribution No data Address AVDA. BLASCO IBAÑEZ, 13 22085 VALENCIA Spain See on map Links Website Opens in new window Total cost No data Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all INTERVALENCE BIOKINETICS S.L. Spain EU contribution No data Address Benjamin Franklin 12. PATERNA See on map Links Website Opens in new window Total cost No data ACROSS BARRIERS GMBH Germany EU contribution No data Address Stuhlsatzenhausweg 69 SAARBRÜCKEN See on map Links Website Opens in new window Total cost No data SOLVO BIOTECHNOLOGY INC. Hungary EU contribution No data Address Béke u. 5/A SZEGED See on map Links Website Opens in new window Total cost No data AUKSTIEJI ALGORITMAI Lithuania EU contribution No data Address Mickeviciaus 29 VILNIUS See on map Links Website Opens in new window Total cost No data NATIONAL MEDICAL CENTER Hungary EU contribution No data Address Szabolcs u. 35. BUDAPEST See on map Links Website Opens in new window Total cost No data INSTITUTE OF ENZIMOLOGY, BIOLOGICAL RESEARCH CENTER, HUNGARIAN ACADEMY OF SCIENCES Hungary EU contribution No data Address Karolina ut 29 BUDAPEST See on map Links Website Opens in new window Total cost No data
