Objective Organ transplantation has emerged as the “gold standard” therapy for end-stage organ failure. Incomplete control of chronic allograft injury but also the adverse effects of long-term immunosuppression (IS) continue to challenge the long-term success of transplantation. The paradigm is shifting from increasing “net”-IS by novel drugs to the concept of minimizing long-term IS as early as possible. However, data were almost completely generated by “trial-and-error” observational studies. It suggests an unmet need to stratify transplant (Tx) patients regarding their immunological responsiveness to the allograft and their respective individual need of IS. The central focus of the project is the implementation of biomarker-driven strategies for personalizing IS to improve the long-term outcome and to decrease the adverse effects and costs of chronic IS. This includes 5 innovative investigator-driven biomarker clinical trials designed by the consortium with >1800 (screening) / 1000 (trial) patients. The following issues will be addressed: -targeted complete/partial weaning of standard IS in long-term stable liver and kidney Tx patients identified as “operationally tolerant” by recently developed biomarker panels-prevention of CNI-based standard IS in low-responder kidney Tx recipients by perioperative biomarker-based stratification-shifting high to low-responder kidney Tx patients suitable for early minimisation by the recently explored selective targeting of alloreactive effector/memory T cells -implementing new biomarker candidates supporting personalized IS within the clinical trials-analysing the health-economic impact of biomarker-guided personalized IS -studying the mechanisms behind successful weaning (regulation/effector balance) -disseminating the results and developing commercialisation by partnering with SME/industry. The project will take advantage and exploit recent research findings–Indices of Tolerance (IOT) and RISET but also of other international groups. Fields of science natural sciencescomputer and information sciencesinternetinternet of thingsmedical and health sciencesclinical medicinetransplantation Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.1.4-1 - Innovative approaches to solid organ transplantation Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator CHARITE - UNIVERSITAETSMEDIZIN BERLIN EU contribution € 1 344 168,00 Address Chariteplatz 1 10117 Berlin Germany See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fräßdorf (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (16) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES France EU contribution € 500 000,00 Address Allee de l'Ile Gloriette 5 44093 Nantes See on map Region Pays de la Loire Pays de la Loire Loire-Atlantique Activity type Higher or Secondary Education Establishments Administrative Contact Sophie Brouard (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 294 600,00 Address WELLINGTON SQUARE UNIVERSITY OFFICES OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Linda Pialek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KING'S COLLEGE LONDON United Kingdom EU contribution € 849 660,00 Address STRAND WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT CATALA DE LA SALUT Spain EU contribution € 500 000,00 Address GRAN VIA DE LES CORTS CATALANES 587 08007 Barcelona See on map Region Este Cataluña Barcelona Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Laia Lagunas (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Institut klinické a experimentální mediciny Czechia EU contribution € 500 000,00 Address Videnska 1958/9 14021 Prague 4 See on map Region Česko Praha Hlavní město Praha Activity type Research Organisations Administrative Contact Tomáš Linhart Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 201 340,00 Address MEIBERGDREEF 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Frank J.M. Groen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KLINIKUM DER UNIVERSITAET REGENSBURG Germany EU contribution € 201 600,00 Address FRANS JOSEF STRAUSS ALLEE 11 93053 Regensburg See on map Region Bayern Oberpfalz Regensburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Elisabeth Geiger (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Germany EU contribution € 201 600,00 Address Martinistrasse 52 20251 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Higher or Secondary Education Establishments Administrative Contact Bjoern Nashan (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CELLOGIC GMBH Germany EU contribution € 199 200,00 Address NIEDSTRASSE 21 12159 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Malte Pietzsch (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IMMUNOTECH SAS France EU contribution € 114 400,00 Address AVENUE JEAN DE LATTRE DE TASSIGNY 130 13009 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Basile Wilhelem (Dr.) Links Contact the organisation Opens in new window Total cost No data Genome Identification Diagnostics GmbH Germany EU contribution € 611 000,00 Address Ebinger Str. 4 72479 Strassberg See on map Region Baden-Württemberg Tübingen Zollernalbkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rosemarie Preyer (Mrs.) Links Contact the organisation Opens in new window Total cost No data MILENIA BIOTEC GMBH Germany EU contribution € 89 832,00 Address VERSAILLER STRASSE 1 35394 GIESSEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ralf Dostatni (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BRISTOL-MYERS SQUIBB GMBH & CO. KGAA Participation ended Germany EU contribution No data Address ARNULFSTRASSE 29 80636 MUNICH See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Anton Hack (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASTELLAS PHARMA EUROPE LTD United Kingdom EU contribution € 76 000,00 Address 2000 HILLSWOOD DRIVE KT16 0RS Chertsey See on map Region South East (England) Surrey, East and West Sussex West Surrey Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Morne Voight (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Italy EU contribution € 229 600,00 Address VIA FIORENTINA 151 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Cristiana Tozzi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TEVA PHARMACEUTICALS EUROPE B.V. Netherlands EU contribution € 76 000,00 Address PIET HEINKADE 107 1019 GM AMSTERDAM See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Carla-Maria Brandes (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data