Objective
Damage to the central nervous system (CNS) often leads to persistent functional deficits, causing
great individual suffering and enormous cost to society. The manifestation of these deficits is
believed to be associated with the scar tissue that forms locally at lesions, causing permanent tissue
alteration and blocking regeneration.
Research on CNS scar tissue has primarily focused on astrocytes and it is often referred to as the
glial scar. However, although it has received much less attention, there is also a connective tissue or
stromal, non-glial, component of the scar.
While studying spinal cord injury-induced scarring, I recently discovered a new subpopulation of
perivascular cells, named type A pericytes, as a major source of connective scar tissue. Type A
pericytes are embedded in the vascular wall but proliferate and leave the blood vessel upon injury,
differentiating into fibroblast-like cells that deposit extracellular matrix to seal the lesion and form
the persistent stromal scar core.
The aim of the proposal is to determine whether type A pericytes are a general source of
pathological connective tissue in the CNS, to understand the nature of type A pericytes, and to
uncover the signaling mechanisms mediating their recruitment. By comparing several different
injury and disease models the proposed research intends to uncover common mechanisms of
scarring and fibrosis and to identify new targets for human treatment after CNS injury.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-StG_20111109
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
171 77 STOCKHOLM
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.