Objective THALAMOSS is aimed at development of universal sets of markers and techniques for stratification of β-thalassaemia patients into treatment subgroups for (a) onset and frequency of blood transfusions, (b) choice of iron chelation, (c) induction of fetal hemoglobin, (d) prospective efficacy of gene-therapy. At present, no framework exists to guide therapeutic decisions and personalised treatment of β-thalassaemia.THALAMOSS Workpackages: WP1. Recruitment, patient characterization and development of erythroid precursor cells cultures; WP2. Omics analyses; WP3. Novel therapeutic approaches; WP4. Data analysis; WP5. Dissemination and exploitation; WP6. Regulatory and ethical issues; WP7. Management.The impact of THALAMOSS is the provision of novel biomarkers for distinct treatment subgroups in β-thalassaemia (500-1000 samples from four European medical centres), identified by combined genomics, proteomics, transcriptomics and tissue culture assays, and establishment of routine techniques for detection of these markers. Translation of these activities into the product portfolio and R&D methodology of participating SMEs will be a major issue. THALAMOSS tools and technologies will (a) facilitate identification of novel diagnostic tests, drugs and treatments specific to patient subgroups and (b) guide conventional and novel therapeutical approaches for β-thalassaemia, including personalised medical treatments.Key researchers of THALAMOSS are R.Gambari (Ferrara University, Italy), M. Kleanthous (The Cyprus Foundation for Muscular Dystrophy Research, Cyprus), S.Philipsen (Erasmus Universitair Medisch Centrum Rotterdam, The Netherlands), E.Katsantoni (Biomedical Research Foundation, Academy of Athens, Greece), S.Rivella (Cornell University, NY, USA - The Children's Hospital of Philadelphia, Philadelphia, USA), P.Holub (Masaryk University, Czech Republic), P. Moi (Cagliari University, Italy), S. Menzel and SL.Thein (King’s College Hospital, UK), E.Voskaridou (Laiko General Hospital, Greece). Participating SMEs are Biocep (Israel), NovaMechanics Ltd. (Cyprus) and IRBM (Italy). Industrial activities are also provided by Harbour Antibodies (The Netherlands). Fields of science natural sciencescomputer and information sciencesdata sciencenatural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicineneurologymuscular dystrophiessocial sciencespolitical sciencesgovernment systems Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.1.2-1 - Development of technologies with a view to patient group stratification for personalised medicine applications Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITA DEGLI STUDI DI FERRARA EU contribution € 584 000,00 Address Via ariosto 35 44121 Ferrara Italy See on map Region Nord-Est Emilia-Romagna Ferrara Activity type Higher or Secondary Education Establishments Administrative Contact Roberto Gambari (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (13) Sort alphabetically Sort by EU Contribution Expand all Collapse all KYPRIAKO IDRYMA EREVNON GIA TI MYIKI DISTROFIA Cyprus EU contribution € 440 000,00 Address 6 iroon avenue 2371 Agios dometios See on map Region Κύπρος Κύπρος Κύπρος Activity type Research Organisations Administrative Contact Marios Flouros (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 370 000,00 Address Dr molewaterplein 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Riet Zeijl (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Greece EU contribution € 370 000,00 Address Soranou efesiou 4 115 27 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Dimitris Raptis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CORNELL UNIVERSITY United States EU contribution € 233 587,33 Address Pine tree road 373 14850 Ithaca ny See on map Activity type Higher or Secondary Education Establishments Administrative Contact Michelle Lewis (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Masarykova univerzita Czechia EU contribution € 320 000,00 Address Zerotinovo namesti 9 601 77 Brno See on map Region Česko Jihovýchod Jihomoravský kraj Activity type Higher or Secondary Education Establishments Administrative Contact Petr Holub (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI CAGLIARI Italy EU contribution € 320 000,00 Address Via universita 40 09124 Cagliari See on map Region Isole Sardegna Cagliari Activity type Higher or Secondary Education Establishments Administrative Contact Tiziana Cubeddu (Mrs.) Links Contact the organisation Opens in new window Total cost No data KING'S COLLEGE LONDON United Kingdom EU contribution € 320 000,00 Address Strand WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Paul Labbett (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GENIKO LAIKO NOSOKOMEIO ATHINON*GENERAL HOSPITAL OF ATHENS LAIKO Greece EU contribution € 320 000,00 Address Agiou thoma 17 11527 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Ersi Voskaridou (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NOVAMECHANICS LIMITED Cyprus EU contribution € 620 477,53 Address Digeni akrita 51 1070 Nicosia See on map Region Κύπρος Κύπρος Κύπρος Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Antreas Afantitis (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOCEPS Israel EU contribution € 97 761,00 Address Ziv medical center, the research department, harambam street 1311001 Tzfat See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eitan Fibach (Prof.) Links Contact the organisation Opens in new window Total cost No data HARBOUR ANTIBODIES BV Netherlands EU contribution € 100 000,00 Address Stationsplein 45, a4.004 3013 AK Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Riet Van Zeijl (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IRBM SPA Italy EU contribution € 787 761,47 Address Via pontina km 30600 00040 Pomezia rm See on map Region Centro (IT) Lazio Roma Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ilaria Iannaccone (Dr.) Links Contact the organisation Opens in new window Total cost No data THE CHILDREN'S HOSPITAL OF PHILADELPHIA NON PROFIT ORG United States EU contribution € 136 412,67 Address Civic center blvd 19104 Philadelphia See on map Activity type Other Administrative Contact Robert Denight (Mr.) Links Contact the organisation Opens in new window Total cost No data