Objective Hematological diseases are highly heterogeneous malignancies in the matter of the molecular mechanisms related to their development and progression. A considerable heterogeneity can be further observed within the same hematological disease at the inter-individual level, being reflected by different clinical outcomes and responses to treatment in different patients. Nowadays, the advent of high-throughput next generation sequencing (NGS) technologies that are revolutionizing genomics and transcriptomics by providing a single base resolution tool for a unified deep analysis of diseases complexity allows a fast and cost-efficient fine-scale assessment of the genetic variability hidden within cohorts of patients affected by the same leukemia. That being so, by potentially highlighting inter-individual differences that may play a role in the differential success of diverse therapeutic interventions, they promise to be crucial for selecting the most appropriate medical treatments. This project aims at developing a European Hematological/NGS platform of scientists for improving outcomes for therapeutic interventions on acute and chronic leukemias and at developing strategies to personalize treatments and tailor therapies to different stratified groups of leukemia patients, with the goal of optimizing their efficacy and safety through a deeper and deeper understanding of the influence of genetic alterations on leukemias pathogenesis and treatment response (i.e. “personalized therapy”). Moreover, the final aim will be the identification of novel prognostic biomarkers for acute and chronic leukemias, as well as of molecular biomarkers and/or genome-wide profiles for the assessment of minimal residual disease. The originality of this project is to perform systematic deep whole exome/transcriptome studies on well-clinically-characterized leukemia patients, by exploiting NGS technologies able to quickly produce data with a good cost-effectiveness and an unprecedented resolution. Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesclinical medicineoncologyleukemia Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.1.2-1 - Development of technologies with a view to patient group stratification for personalised medicine applications Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA EU contribution € 942 941,55 Address Via zamboni 33 40126 Bologna Italy See on map Region Nord-Est Emilia-Romagna Bologna Activity type Higher or Secondary Education Establishments Administrative Contact Valeria Genovesi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITA DEGLI STUDI DI TORINO Italy EU contribution € 546 900,00 Address Via giuseppe verdi 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Administrative Contact Massimiliano Lauria (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PERSONAL GENOMICS SRL Italy EU contribution € 795 719,10 Address Via roveggia 43 37136 Verona See on map Region Nord-Est Veneto Verona Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Massimo Delledonne (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SINAPTICA IT SRL Italy EU contribution € 499 400,00 Address Via collalto sabino 20 00199 Roma See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Marco Capoferri (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAET ULM Germany EU contribution € 449 600,00 Address Helmholtzstrasse 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Frank Gleixner (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 500 002,71 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Myriam Witvrouw (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FASTERIS SA Switzerland EU contribution € 549 400,00 Address Chemin du pont du centenaire 109 1228 Plan les ouates See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Laurent Farinelli (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Masarykova univerzita Czechia EU contribution € 396 720,00 Address Zerotinovo namesti 9 601 77 Brno See on map Region Česko Jihovýchod Jihomoravský kraj Activity type Higher or Secondary Education Establishments Administrative Contact Katerina Pejchalova (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION DE INVESTIGACION DEL CANCER DE LA UNIVERSIDAD DE SALAMANCA Spain EU contribution € 399 681,64 Address Campus miguel de unamuno 37007 Salamanca See on map Region Centro (ES) Castilla y León Salamanca Activity type Research Organisations Administrative Contact Antonio Mata Dominguez (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MLL MUNCHNER LEUKAMIELABOR GMBH Germany EU contribution € 790 450,00 Address Max lebsche platz 31 81377 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Torsten Haferlach (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data