Objective
Cell proliferation lies at the heart of the threat posed by tumours. It involves cellular growth, division and migration. The tissue surrounding a tumor physically limits its proliferation, which implies that cells that are able to produce effective tumour growth, as well as cells that migrate out of the original tumour, have been able to circumvent this physical limitation. Other factors in tissues, however, can contribute to stop cell proliferation, making it difficult to precisely evaluate the contribution of physical confinement. In this project I propose to specifically address the effect of physical confinement on normal and cancer cells that are dividing and migrating, using new pathophysiologically relevant in vitro approaches. More specifically I propose two main objectives, related to the pathogenic potential of tumour cells:
1) Discover specific mechanisms that allow dividing cells to push surrounding tissue (a process known as mitotic cell rounding) and demonstrate that alterations in this process can lead to spindle assembly defects and eventually to mitotic cell death. This will open a new set of targets to specifically kill dividing tumour cells.
2) Discover specific mechanisms that allow migrating cells to squeeze their nucleus through narrow gaps. The nucleus has been shown to be the main physical barrier to cell migration in tissues, and two types of cells are able to migrate through narrow gaps: immune cells and metastatic cells. By comparing these two types of cells, we hope to uncover mechanisms specific to metastatic cells, thus providing targets for anti-metastatic treatments that would not harm immune cells function.
Understanding how cancer cells can achieve efficient proliferation and migration under external constraints will aid the design of new anti-cancer strategies. These strategies would be based on targeting these specific processes identified to be essential for cancer cells to circumvent physical constraints they encounter in vivo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-StG_20111109
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75231 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.