Objective
"The epidemiological study of Tinea capitis (ringworm) patients has proven useful for the study of carcinogenic effects of low dose radiation. In Dark.risk we will develop a new epidemiological cohort based upon the 24 000 cases irradiated in childhood that we will document to create the Serbian Registry of Tinaea Capitis Children (SRTCC). Unlike many other epidemiological cohorts SRTCC can be used to collect biological materials for molecular epidemiological studies.
Dark.risk will prepare the way to use SRTCC biomaterials to quantify the contribution of individual differences in sensitivity to risk from low doses of ionizing radiation. We will focus on a novel and unique process to identify individual differences. Until recently 95% of the human genome was considered to be non-translated “junk"" DNA. However, almost all of this “dark matter” is actively transcribed into a vareity of non-coding RNA species (ncRNAs) that regulate interactions with the external environment, such as repressing retrotransposons, regulating gene transcription responses to stress, governing chromatic remodeling and coordinating the translation of mRNAs. The ncRNAs play an essential role in coordinating critical cellular responses to radiation such as maintenance of genomic stability, senescence, apoptosis and survival. As ncRNAs make major contributions to individual disease sensitivity we will investigate precisly how the “dark matter” regulates responses at low doses (1mGy to 500mGy), and how these responses vary between individuals.
Our long-term goal is to use ncRNAs as biological markers of exposure and outcome on an individual basis."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences nuclear physics
- natural sciences physical sciences astronomy astrophysics dark matter
- natural sciences biological sciences genetics RNA
- engineering and technology industrial biotechnology biomaterials
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-Fission-2012
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
85764 Neuherberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.