Objetivo "The epidemiological study of Tinea capitis (ringworm) patients has proven useful for the study of carcinogenic effects of low dose radiation. In Dark.risk we will develop a new epidemiological cohort based upon the 24 000 cases irradiated in childhood that we will document to create the Serbian Registry of Tinaea Capitis Children (SRTCC). Unlike many other epidemiological cohorts SRTCC can be used to collect biological materials for molecular epidemiological studies.Dark.risk will prepare the way to use SRTCC biomaterials to quantify the contribution of individual differences in sensitivity to risk from low doses of ionizing radiation. We will focus on a novel and unique process to identify individual differences. Until recently 95% of the human genome was considered to be non-translated “junk"" DNA. However, almost all of this “dark matter” is actively transcribed into a vareity of non-coding RNA species (ncRNAs) that regulate interactions with the external environment, such as repressing retrotransposons, regulating gene transcription responses to stress, governing chromatic remodeling and coordinating the translation of mRNAs. The ncRNAs play an essential role in coordinating critical cellular responses to radiation such as maintenance of genomic stability, senescence, apoptosis and survival. As ncRNAs make major contributions to individual disease sensitivity we will investigate precisly how the “dark matter” regulates responses at low doses (1mGy to 500mGy), and how these responses vary between individuals.Our long-term goal is to use ncRNAs as biological markers of exposure and outcome on an individual basis." Ámbito científico natural sciencesphysical sciencesnuclear physicsnatural sciencesphysical sciencesastronomyastrophysicsdark matternatural sciencesbiological sciencesgeneticsRNAengineering and technologyindustrial biotechnologybiomaterialsnatural sciencesbiological sciencesgeneticsgenomes Programa(s) FP7-EURATOM-FISSION - EURATOM: Nuclear fission and radiation protection Tema(s) Fission-2012-3.1.1 - Contribution to low-dose risk research in Europe Convocatoria de propuestas FP7-Fission-2012 Consulte otros proyectos de esta convocatoria Régimen de financiación CP - Collaborative project (generic) Coordinador HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH Aportación de la UE € 640 612,00 Dirección INGOLSTADTER LANDSTRASSE 1 85764 Neuherberg Alemania Ver en el mapa Región Bayern Oberbayern München, Landkreis Tipo de actividad Research Organisations Contacto administrativo Juergen Ertel (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo "ZENSKA ASOCIJACIJA ""ROSA""" Serbia Aportación de la UE € 148 233,00 Dirección LUKE VOJVODICA 35 11000 BEOGRAD Ver en el mapa Tipo de actividad Research Organisations Contacto administrativo Marija Tasic (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE Italia Aportación de la UE € 309 318,00 Dirección LUNGOTEVERE GRANDE AMMIRAGLIO THAON DI REVEL 76 00196 Roma Ver en el mapa Región Centro (IT) Lazio Roma Tipo de actividad Research Organisations Contacto administrativo Annamaria Margari (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITAT AUTONOMA DE BARCELONA España Aportación de la UE € 353 287,00 Dirección EDIF A CAMPUS DE LA UAB BELLATERRA CERDANYOLA V 08193 Cerdanyola Del Valles Ver en el mapa Región Este Cataluña Barcelona Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Francisca Rabadán Sotos (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos SERVIZO GALEGO DE SAUDE España Aportación de la UE € 278 550,00 Dirección Edificio Administrativo San Lázaro 15703 Santiago De Compostela Ver en el mapa Región Noroeste Galicia A Coruña Tipo de actividad Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Contacto administrativo Jose-Luis Fernandez-Garcia (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
