Risk, Stem Cells and Tissue Kinetics – Ionising Radiation

Project Information

RISK - IR

Grant agreement ID: 323267

Project closed

Start date 1 November 2012

End date 30 April 2017

Funded under

• EURATOM: Nuclear fission and radiation protection

Total cost € 8 598 495,83

EU contribution € 6 685 000,00

Coordinated by

Department of Health
United Kingdom

Objective

The magnitude of cancer risk in humans exposed to low radiation doses (<100mSv) is uncertain and depends upon extrapolation of human population based estimates obtained at higher doses. The linear non-threshold extrapolation model currently used has some support from mechanistic/biophysical considerations but it is not based on understanding of the biological responses of the cells of origin for radiation cancer. Stem cells are widely recognised as the cells of origin for many cancers. Understanding the responses of stem cells to low radiation doses will be important therefore in providing mechanistic support for low dose cancer risk extrapolation. In this project, techniques emerging from stem cell biological and tissue kinetics research will be used to address several major areas of uncertainty in low dose (<100 mGy) cancer risk estimates:

1. The identification and enumeration of stem/progenitor cells at risk
2. Understanding low dose radio-sensitivity of stem cells and tissues.
3. Improving understanding of mechanisms of age-dependant cancer risk
4. Improving understanding of tissue specific differences in cancer risk.
5. Identification of key events and individual susceptibility factors associated with cancer development.

The primary output of the RISK-IR project will be peer reviewed scientific papers. Considerable efforts will be made to consolidate scientific evidence of relevance for radiation protection through reviews and dissemination of project results and implications to radiation protection specialists will be facilitated through a stakeholder meeting in the final year of the project.

Fields of science

• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › oncology

Programme(s)

• FP7-EURATOM-FISSION - EURATOM: Nuclear fission and radiation protection

Topic(s)

• Fission-2012-3.1.1 - Contribution to low-dose risk research in Europe

Call for proposal

FP7-Fission-2012
See other projects for this call

Funding Scheme

CP - Collaborative project (generic)

Coordinator

Department of Health

• EU contribution: € 1 292 548,00
• Address: Quarry House, Quarry Hill ; LS2 7UE Leeds ; United Kingdom
• Region: Yorkshire and the Humber › West Yorkshire › Leeds
• Activity type: Research Organisations
• Administrative Contact: Paul Barty (Mr.)
• Total cost: No data

Participants (12)

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

• EU contribution: € 2 029 427,00
• Address: RUE LEBLANC 25 ; 75015 PARIS 15
• Region: Ile-de-France › Ile-de-France › Paris
• Activity type: Research Organisations
• Administrative Contact: Michele Martin (Dr.)
• Total cost: No data

UNIVERSITA DEGLI STUDI DELLA CAMPANIA LUIGI VANVITELLI

Italy

• EU contribution: € 344 400,00
• Address: VIALE ABRAMO LINCOLN 5 ; 81100 Caserta
• Region: Sud › Campania › Caserta
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Umberto Galderisi (Prof.)
• Total cost: No data

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

• EU contribution: € 294 295,00
• Address: INGOLSTADTER LANDSTRASSE 1 ; 85764 Neuherberg
• Region: Bayern › Oberbayern › München, Landkreis
• Activity type: Research Organisations
• Administrative Contact: Jürgen Ertel (Dr.)
• Total cost: No data

ACADEMISCH ZIEKENHUIS LEIDEN

Netherlands

• EU contribution: € 622 520,00
• Address: ALBINUSDREEF 2 ; 2333 ZA Leiden
• Region: West-Nederland › Zuid-Holland › Agglomeratie Leiden en Bollenstreek
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Liesbeth Dorama (Ms.)
• Total cost: No data

THE UNIVERSITY OF SUSSEX

United Kingdom

• EU contribution: € 481 035,00
• Address: SUSSEX HOUSE FALMER ; BN1 9RH Brighton
• Region: South East (England) › Surrey, East and West Sussex › Brighton and Hove
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Bettina Lehmbeck (Ms.)
• Total cost: No data

FUNDACION SECTOR PUBLICO ESTATAL CENTRO NACIONAL INVESTIGACIONES ONCOLOGICAS CARLOS III

Spain

• EU contribution: € 399 244,00
• Address: C MELCHOR FERNANDEZ ALMAGRO 3 ; 28029 Madrid
• Region: Comunidad de Madrid › Comunidad de Madrid › Madrid
• Activity type: Research Organisations
• Administrative Contact: Dolores Liebanes (Dr.)
• Total cost: No data

MEDICAL RESEARCH COUNCIL

Participation ended

United Kingdom

• EU contribution: € 23 251,00
• Address: 20 Park Crescent ; W1B 1AL LONDON
• Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
• Administrative Contact: Phil Jones (Dr.)
• Total cost: No data

UNIVERSITE LIBRE DE BRUXELLES

Belgium

• EU contribution: € 391 800,00
• Address: AVENUE FRANKLIN ROOSEVELT 50 ; 1050 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Panagiota Sotiropoulou (Dr.)
• Total cost: No data

TECHNISCHE UNIVERSITAT DARMSTADT

Germany

• EU contribution: € 396 480,00
• Address: KAROLINENPLATZ 5 ; 64289 Darmstadt
• Region: Hessen › Darmstadt › Darmstadt, Kreisfreie Stadt
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Markus Lobrich (Prof.)
• Total cost: No data

HEALTH PROTECTION AGENCY HPA

Participation ended

United Kingdom

• EU contribution: No data
• Address: BUCKINGHAM PALACE ROAD 151 ; SW1W 9SZ London
• Activity type: Research Organisations
• Administrative Contact: Anne Dempsey (Mrs.)
• Total cost: No data

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

Participation ended

United Kingdom

• EU contribution: € 122 210,38
• Address: TRINITY LANE THE OLD SCHOOLS ; CB2 1TN Cambridge
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Dimple Fernado (Mrs.)
• Total cost: No data

GENOME RESEARCH LIMITED

United Kingdom

• EU contribution: € 287 789,62
• Address: WELLCOME SANGER INSTITUTE WELLCOME GENOME CAMPUS HINXTON ; CB10 1SA SAFFRON WALDEN
• Region: East of England › East Anglia › Cambridgeshire CC
• Activity type: Research Organisations
• Administrative Contact: Martin Dougherty (Dr.)
• Total cost: No data