Objective
The aim of this proposal is to establish a business plan for the development of a new class of Functional Biomarkers as in vitro diagnostic tools for managing patients with chronic disease. The proof of concept will be established by focusing on substrates of the X-prolyl dipeptidylpeptidases (DPP), a family of pleotropic enzymes that cleave the N-terminal two amino acids of proteins. There are >30 known substrates for DPPIV, the best characterized member of this family. Importantly the catalytic activity of DPPIV results in the conversion of agonist ligands into antagonist or non-functional proteins.
In the context of our funded ERC project, we have provided the first in vivo evidence of DPPIV-mediated cleavage of the chemokine interferon-induced protein 10 (IP-10 or CXCL10) [Casrouge, JCI 2011]. These initial observations have recently been validated, conclusively demonstrating the ability to predict treatment failure in chronic HCV patients (p-value <0.001 for antagonist CXCL10 and negative predictive value = 93.5%).
Based on the important role of DDPIV in disease pathogenesis and following from our findings, there are two ideas that we wish to develop further as proof of concept for ‘Functional Biomarkers’ in the management of patients. First, we wish to evaluate the market needs for developing a privately run SME, aimed at providing theragnostic testing useful for stratification of chronic HCV patients. We will also examine the potential value of applying these in vitro diagnostic (IVD) tools in other disease settings in which DPPIV and/or CXCL10 have been identified as a predictive biomarker. Second, we aim to extend our repertoire of assays to include other disease relevant DPPIV substrates.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences infectious diseases RNA viruses hepatitis C
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-PoC
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.