BIP-UPyProject reference: 310389
Funded under :
Bioactive Implantable Polymers based on UreidoPyrimidinone
Total cost:EUR 5 918 893,8
EU contribution:EUR 4 500 852
Call for proposal:FP7-NMP-2012-LARGE-6See other projects for this call
Funding scheme:CP-IP - Large-scale integrating project
BIP-UPy addresses the need for biomedical implants which can be easily fine-tuned in their properties in regards to bioactivity, biodegradability, and mechanical performance, and thereby be optimized for their targeted clinical application.
This project will develop a library comprising of a selection of synthetic polymers and specific bioactivities which can be used to provide the required properties for a targeted biomedical implant.
The polymeric materials that will be addressed are supramolecular UPy-modified polymers for uses in urologic implants and embolic implants, benefitting large population groups: bio-degradable meshes with improved in-situ tissue regeneration in pelvic floor repair and endovascular embolic implants with a reduced aneurysm recurrence risk.
A mix-and-match approach will be used to bioactivate these supramolecular base materials. The supramolecular nature of the materials allows for mild processing conditions.
Main objective is to develop a methodology for obtaining implantable polymers with specifically designed bioactivity for in-situ Tissue Engineering, in which the medical implant is obtained in one step by co-processing of the peptide molecules with the neat polymeric material.
Key deliverables are protocols for processable biocompatible UPy-based polymers synthesis and manufacturing scale-up; protocols for UPy-based polymers bioactivity tailoring; procedures for processing the UPy-based polymers preserving the bioactivity efficiency; sterilisation protocols for bioactive medical implants; bioactive implants prototypes with tailored bioactivities; material and implant biocompatibility and bioactivity tests data; new predictive in-vitro tests and drafts of regulatory docs.
BIP-UPy consortium comprises 9 partners from 5 European countries: 3 RTD performing institutions and 2 Hospitals, 3 SMEs and 1 LE representing the strong industrial involvement.
Forth SME (CHEMPILOTS-DK) has whithdrawn from project on 31/12/2014.
EU contribution: EUR 533 606,2
AVENIDA UNIVERSITAT AUTONOMA 23
08290 CERDANYOLA DEL VALLES (BARCELONA)
08290 CERDANYOLA DEL VALLES
EU contribution: EUR 592 920
5612 AX EINDHOVEN
EU contribution: EUR 555 675
DEN DOLECH 2
5612 AZ EINDHOVEN
EU contribution: EUR 396 486
ULICA ZEROMSKIEGO 116
90 924 LODZ
EU contribution: EUR 341 796,8
EU contribution: EUR 433 920
PASEO MIKELETEGI - PARQUE TECNOLOGICO MIRAMON 2
20009 DONOSTIA SAN SEBASTIAN
Tel.: +34 93 5944726
Fax: +34 93 5944737
EU contribution: EUR 289 500
EU contribution: EUR 174 548
EU contribution: EUR 551 000
Oude Markt 13
EU contribution: EUR 631 400
5611 ZS EINDHOVEN
Tel.: +31 40 2474837