Cel Future treatment of incurable neurodegenerative disorders, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), spinocerebellar ataxia (SCA), and Huntington’s disease (HD), has to be tailored to individual patients or cohorts of patients to obtain an optimal effect. The STEMMAD project is aimed to create a highly innovative international collaboration between 2 R&D intensive SME and 3 distinguished academic partners, including one ICPC Third Country partner. The program will enhance the competitiveness of the SME partners and will have a great impetus in an area of immense societal importance: Neurodegenerative diseases and their potential cure. It is our overall aim, by advanced molecular tools, to derive patient-specific in vitro neural cell models that will allow for such customized treatment. Skin biopsies and blood samples will be collected from genetically and clinically well-characterized patients. Fibroblasts and mononuclear blood cells will be isolated and reprogrammed into induced pluripotent stem cells (iPSCs), which, in turn, will be differentiated into neural progenitor cells (NPCs) and specific neurons. We expect that these neurons will express molecular characteristics of the patient’s “disease phenotype” and thereby be representative as patient-specific neural cell models. The models will be characterized for functional disease parameters, used for studies of molecular pathogenesis. The iPSC reprogramming and neural differentiation will be controlled by advanced molecular technologies including manipulation of microRNA (miRNA) expression as well as the use of plasmid minicircles with reprogramming factor genes, thus leaving the genome free of transgenes. To ensure the success of the project, direct transdifferentiation of fibroblasts into neurons, without an intermediate “stem cell” stage, will also be attempted as an alternative strategy for generating patient-specific neural cell models. Dziedzina nauki medical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2012-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Zaproszenie do składania wniosków FP7-PEOPLE-2012-IAPP Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Koordynator KOBENHAVNS UNIVERSITET Wkład UE € 1 047 562,89 Adres NORREGADE 10 1165 Kobenhavn Dania Zobacz na mapie Region Danmark Hovedstaden Byen København Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Ivan Kristoffersen (Mr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Uczestnicy (4) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko BIOTALENTUM TUDASFEJLESZTO KFT Węgry Wkład UE € 499 914,14 Adres AULICH LAJOS UTCA 26 2100 Goedoello Zobacz na mapie Region Közép-Magyarország Pest Pest Rodzaj działalności Private for-profit entities (excluding Higher or Secondary Education Establishments) Kontakt administracyjny Ocsovszky Zsofia (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych BIONEER A/S Dania Wkład UE € 603 796,97 Adres KOGLE ALLE 2 2970 Hoersholm Zobacz na mapie Region Danmark Hovedstaden Nordsjælland Rodzaj działalności Research Organisations Kontakt administracyjny Christian Clausen (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych MAHIDOL UNIVERSITY Tajlandia Wkład UE € 212 486,29 Adres RATCHAWITHI ROAD 420/6 10400 Bangkok Zobacz na mapie Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Narisorn Kitiyanant (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych SZEGEDI TUDOMANYEGYETEM Węgry Wkład UE € 418 649,44 Adres DUGONICS TER 13 6720 Szeged Zobacz na mapie Region Alföld és Észak Dél-Alföld Csongrád Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Botond Penke (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
