Objectif In chronic joint disease, only a subgroup of patients has classical autoantibodies, while the other variants are seronegative arthritis syndromes with a predominance of innate immune disturbances. These forms of joint diseases frequently show extra-articular manifestations of epithelial tissues like skin and gut. On the molecular level, innate immune activation and the release of damage associated molecular pattern proteins (DAMPs) of the S100 family are important mechanisms of initiation and perpetuation. Early diagnosis remains a significant problem, and prediction of disease extension and course is challenging. Despite all efforts we do not have therapies that alleviate the disease and protect from disease progression, damage and long-term disability. The identification of specific inflammatory mechanisms that correlate to patterns of disease characteristics would allow targeted therapeutic approaches. In a comprehensive research approach, MIAMI will establish relevant disease mechanisms and translate finding into novel biomarkers for individual adaptation of therapies (personalised medicine) for seronegative arthritis. Our research strategy leaves retracted ways of genetics and classical autoimmunity; instead we will focus on innate immunity and inflammation. The goals of MIAMI are ambitious and will be reached with cutting-edge research performed by the most excellent researchers in the field, who have been combined to form a multidisciplinary consortium. The choice of the scientific as well as industry partners was entirely based on excellence. Thus, MIAMI brings together the leading teams that are working on mechanisms of innate immunity in arthritis and mucosal inflammation. In summary, MIAMI will significantly contribute to progress on the key questions: Who will be affected by which disease manifestation or complication, how can we use this knowledge to identify the disease, and what will be a meaningful target to treat or even prevent deleterious outcome. Champ scientifique natural sciencesbiological sciencesgeneticsmedical and health sciencesclinical medicinerheumatologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health scienceshealth sciencespersonalized medicine Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2012.2.4.5-2 - Biomarkers and diagnostics for chronic inflammatory diseases of the joints and/or digestive system Appel à propositions FP7-HEALTH-2012-INNOVATION-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur Westfälische Wilhelms-Universität Münster Contribution de l’UE € 1 252 400,00 Adresse SCHLOSSPLATZ 2 48149 MUENSTER Allemagne Voir sur la carte Région Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Julija Winschel (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire STICHTING RADBOUD UNIVERSITEIT Pays-Bas Contribution de l’UE € 581 348,00 Adresse HOUTLAAN 4 6525 XZ Nijmegen Voir sur la carte Région Oost-Nederland Gelderland Arnhem/Nijmegen Type d’activité Higher or Secondary Education Establishments Contact administratif Peter Van Lent (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITEIT GENT Belgique Contribution de l’UE € 824 770,00 Adresse SINT PIETERSNIEUWSTRAAT 25 9000 Gent Voir sur la carte Région Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Type d’activité Higher or Secondary Education Establishments Contact administratif Nathalie Vandepitte (Mrs.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITAIR MEDISCH CENTRUM UTRECHT Pays-Bas Contribution de l’UE € 640 940,00 Adresse HEIDELBERGLAAN 100 3584 CX Utrecht Voir sur la carte Région West-Nederland Utrecht Utrecht Type d’activité Higher or Secondary Education Establishments Contact administratif Anne-Marie Laeven-De Boer (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Irlande Contribution de l’UE € 774 039,00 Adresse BELFIELD 4 Dublin Voir sur la carte Région Ireland Eastern and Midland Dublin Type d’activité Higher or Secondary Education Establishments Contact administratif Donal Doolan (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée BIOGAZELLE NV Belgique Contribution de l’UE € 392 604,00 Adresse TECHNOLOGIEPARK 82 9052 Zwijnaarde Voir sur la carte Région Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Barbara D'haene (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée BUHLMANN LABORATORIES AG Suisse Contribution de l’UE € 1 118 044,00 Adresse BASELSTRASSE 55 4124 SCHONENBUCH Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Oliver Grether (Mr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée EUROPEAN RESEARCH SERVICES GMBH Allemagne Contribution de l’UE € 119 000,00 Adresse HUEFFERSTR. 5 48149 Muenster Voir sur la carte Région Nordrhein-Westfalen Münster Münster, Kreisfreie Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Oliver Panzer (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée