Objective
Defining and characterising the defective genes in hereditary cancer syndromes has advanced our understanding of cellular function and disease mechanisms. Interestingly, some of these genes have been directly implicated in metabolic dysregulation, thus providing a link between genetic mutation and altered metabolism in cancer. One such syndrome, hereditary leiomyomatosis and renal cell cancer (HLRCC), is caused by germline mutations in the FH gene encoding the Krebs cycle enzyme fumarate hydratase. The aim of this proposal is to define pathways disrupted in HLRCC and within these to determine specific points, susceptible to genetic or chemical intervention, from which therapies might be derived to treat or prevent tumourigenesis. First, we will assess candidate mechanisms for FH-associated tumourigenesis which we have identified through recent studies, encompassing enzyme inhibition, protein modification, anti-oxidant signalling and altered energy metabolism. Secondly, to identify novel RCC associated mutations and clarify their relevance in the evolution and metabolism of RCC, transposon-based mutagenesis will be employed to induce RCCs in both wildtype and Fh1-deficient mice. Analyses will include histological analysis, metabolite profiling, and high resolution sequencing. Candidate genes will then be screened in relevant human RCC and pre-malignant lesions. Finally, a synthetic lethality screen will be performed in parallel with metabolic profiling to identify the pathways that are critical for the growth of FH-null cells. Taken together it is envisaged that this work will not only provide insights into this rare but aggressive disease but also inform on potential targets for intervention in more common cancers that are also characterised by metabolic dysregulation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-StG_20111109
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
EH8 9YL Edinburgh
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.