Objective
Currently the most widely used drugs for the treatment of cancer are platinum compounds, used in nearly 50% of all chemotherapeutic regimens. However the platinums can suffer from problems of resistance, a limited spectrum of activity, and side-effects. Hence new agents with new mechanisms of action are urgently needed. We have discovered novel organometallic osmium and iridium compounds with more potent anticancer activity and unique mechanisms of action. Initial work on an osmium compound has demonstrated promising activity against colorectal cancer without toxic side-effects, providing an opportunity to satisfy unmet clinical needs.
The ERC PoC funding will allow the discovery phase to be advanced, to turn hits into leads by establishing and validating target sites, and elucidating mechanisms of action. The techniques employed to achieve this PoC will combine high throughput proteomcs/genomics approaches with image analysis of cancer cell morphology in a mathematical analysis to determine the mechanism of action. Data from cancer models will validate the efficacy of the most active compounds. This portfolio of data, together with desk research on potential patient populations, will provide a strong basis for attracting a partner in the next stage of preclinical development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences mathematics pure mathematics mathematical analysis
- medical and health sciences clinical medicine oncology colorectal cancer
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-PoC
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
CV4 8UW COVENTRY
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.