Objective Nature is able to carry out numerous parallel reactions transforming countless chemical compounds in a single cell. For the stereoselective synthesis of complex, biologically relevant molecules, such as pharmaceuticals and agrochemicals, chemists both in academia and industry typically still use “stop and go” procedures with all its disadvantages, such as the isolation and purification of intermediates after each step causing a lot of waste and high costs.Since around the turn of the millennium, the research area of organocatalysis has grown with a breathtaking speed and can now be seen as a third pillar of catalysis beside bio- and metal catalysis. Very recently, organocatalytic multi-component domino reactions came into the focus of synthetic chemistry by mimicking Nature’s enzymatic cascades.Based on our pioneering contributions in this field of asymmetric organodomino catalysis we aim at developing novel simple, triple, quadruple and even more complex organocascade protocols as well as sequential one-pot-procedures thereby significantly advancing the strategic arsenal for the synthesis of complex biologically active enantiopure compounds bearing multiple stereocenters. Spectroscopic and kinetic studies, especially high resolution ESI-MS measurements which opens an insight into a running domino reaction and accompanying theoretical calculations (in cooperation) will allow a deep mechanistic understanding. The combination of organocatalysis with metal, especially gold catalysis will pave the way for completely new environmentally benign and “green” enantioselective multi-component one-pot techniques scalable for future industrial applications. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural scienceschemical sciencescatalysisnatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-PE5 - ERC Advanced Grant - Materials and Synthesis Call for proposal ERC-2012-ADG_20120216 See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Host institution RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN EU contribution € 2 435 600,00 Address TEMPLERGRABEN 55 52062 Aachen Germany See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Higher or Secondary Education Establishments Principal investigator Dieter Enders (Dr.) Administrative Contact Ernst Schmachtenberg (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Germany EU contribution € 2 435 600,00 Address TEMPLERGRABEN 55 52062 Aachen See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Higher or Secondary Education Establishments Principal investigator Dieter Enders (Dr.) Administrative Contact Ernst Schmachtenberg (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
