Objective
Nature is able to carry out numerous parallel reactions transforming countless chemical compounds in a single cell. For the stereoselective synthesis of complex, biologically relevant molecules, such as pharmaceuticals and agrochemicals, chemists both in academia and industry typically still use “stop and go” procedures with all its disadvantages, such as the isolation and purification of intermediates after each step causing a lot of waste and high costs.
Since around the turn of the millennium, the research area of organocatalysis has grown with a breathtaking speed and can now be seen as a third pillar of catalysis beside bio- and metal catalysis. Very recently, organocatalytic multi-component domino reactions came into the focus of synthetic chemistry by mimicking Nature’s enzymatic cascades.
Based on our pioneering contributions in this field of asymmetric organodomino catalysis we aim at developing novel simple, triple, quadruple and even more complex organocascade protocols as well as sequential one-pot-procedures thereby significantly advancing the strategic arsenal for the synthesis of complex biologically active enantiopure compounds bearing multiple stereocenters. Spectroscopic and kinetic studies, especially high resolution ESI-MS measurements which opens an insight into a running domino reaction and accompanying theoretical calculations (in cooperation) will allow a deep mechanistic understanding. The combination of organocatalysis with metal, especially gold catalysis will pave the way for completely new environmentally benign and “green” enantioselective multi-component one-pot techniques scalable for future industrial applications.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences catalysis
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-ADG_20120216
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
52062 Aachen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.