Objectif The search for the fundamental mechanisms of learning and experience-dependent memory formation in the brain has long been a central quest in neuroscience. The neocortex is a particularly relevant region for plasticity because it is involved in sensory, motor, and cognitive tasks with strong learning components. However, despite many years of intensive research our knowledge of the neuronal mechanisms of plasticity on the level of single synapses in the intact living brain is still very limited.Here I propose the use of cutting edge technology, including the ultrasensitive LOTOS procedure of in vivo two-photon calcium imaging that was developed in our laboratory, to investigate for the first time the functional properties and the plasticity of signal synapses in auditory cortical pyramidal neurons of layers 2/3, 4 and 5 in vivo. For the study of the cellular determinants of synaptic plasticity we will focus on an associative learning paradigm underlying cued fear conditioning. Importantly, this paradigm can be rapidly and effectively induced not only in awake, but also in anesthetized animals and is therefore ideally suited for these studies. In addition to a comprehensive analysis of wild type animals, we will perform experiments in mouse models of Alzheimer’s disease (AD), aiming to identify the cellular cause of the devastating impairment of memory formation observed in patients suffering from AD. Champ scientifique natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologydementiaalzheimernatural scienceschemical sciencesinorganic chemistryalkaline earth metals Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) ERC-AG-LS5 - ERC Advanced Grant - Neurosciences and neural disorders Appel à propositions ERC-2012-ADG_20120314 Voir d’autres projets de cet appel Régime de financement ERC-AG - ERC Advanced Grant Institution d’accueil TECHNISCHE UNIVERSITAET MUENCHEN Contribution de l’UE € 2 404 800,00 Adresse Arcisstrasse 21 80333 Muenchen Allemagne Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Ulrike Ronchetti (Ms.) Chercheur principal Arthur Konnerth (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Bénéficiaires (1) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire TECHNISCHE UNIVERSITAET MUENCHEN Allemagne Contribution de l’UE € 2 404 800,00 Adresse Arcisstrasse 21 80333 Muenchen Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Ulrike Ronchetti (Ms.) Chercheur principal Arthur Konnerth (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
