Obiettivo Chemotherapy is the standard care for the treatment of non-small cell lung carcinoma (NSCLC) patients, however most of non-small cell lung cancer tumours are not sensitive to this treatment. As an alternative to chemoterapy, target therapy with gefitinib (epidermal growth factor receptor-tyrosine kinase inhibitor) has been used in clinical practice in patients with tumours harbouring mutations in EGFR gene, improving their treatment effectiveness. For that reason EGFR mutations analysis should be perform to support the treatment decision for a patient with NSCLC. Despite all the foreseen benefits of EGFR genotyping, the current PCR-based methods used have been shown some associated bottlenecks: i) use of complex samples (tumour biopsy embedded in Formalin Fixed Paraffin, FFPE), ii) require a better understanding from the clinical geneticist to accurately interpret the information provided and to setup the best line of therapy and treatment and iii) the assays are quite expensive and time-consuming. New age diagnostic tools, such as microfluidic platforms and nanodiagnostics are emerging technologies for DNA analysis requiring lower sample volumes and providing comparable sensitivity and specificity at lower costs. Nonetheless, sample preparation and detection of the result of a chemical analysis on-chip are still weak points in many lab-on-a-chip devices. The current proposal, aiming the integration of “all laboratory-based process steps” in one single step, is both challenging and feasible: development of a microfluidic chip that combines blood sample processing (DNA extraction/purification, multiplex amplification) and detection of EGFR mutations in tumour DNA by means of gold and silver-nanoparticles (Ag and Au-nanoprobes). Furthermore a microfluidic chip analyser with an integrated user-friendly software to report genotyping results will be developed. Campo scientifico natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsnatural sciencesbiological sciencesgeneticsDNAengineering and technologyother engineering and technologiesmicrotechnologylab on a chipmedical and health sciencesclinical medicineoncologylung cancernatural sciencesbiological sciencesgeneticsmutation Programma(i) FP7-SME - Specific Programme "Capacities": Research for the benefit of SMEs Argomento(i) SME-2012-1 - Research for SMEs Invito a presentare proposte FP7-SME-2012 Vedi altri progetti per questo bando Meccanismo di finanziamento BSG-SME - Research for SMEs Coordinatore STAB VIDA INVESTIGACAO E SERVICOS EM CIENCIAS BIOLOGICAS LDA Contributo UE € 301 782,00 Indirizzo RUA DOS INVENTORES S/N EDIFICIO MADAN PARQUE SALAS 2.18 E 2.19 2825 182 Caparica Portogallo Mostra sulla mappa Regione Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Orfeu Flores (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (6) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto MICROLIQUID SL Spagna Contributo UE € 405 355,60 Indirizzo AVENIDA URIBARRI 19-1 SAIOLAN 20500 ARRASATE MONDRAGON Mostra sulla mappa Regione Noreste País Vasco Gipuzkoa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Borja Barredo (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato MOLTECH SRL Italia Contributo UE € 339 213,40 Indirizzo VIA ROMA 72 86074 FILIGNANO IS Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Giovanni Ugo Altieri (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato FUNDACAO DA FACULDADE DE CIENCIAS E TECNOLOGIA DA UNIVERSIDADE NOVA DE LISBOA. Portogallo Contributo UE Nessun dato Indirizzo Campus de Caparica, Quinta da Torre S/N 2829516 Caparica Mostra sulla mappa Regione Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Tipo di attività Research Organisations Contatto amministrativo Ana Luísa Baião (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF HULL Regno Unito Contributo UE Nessun dato Indirizzo COTTINGHAM ROAD HU6 7RX Hull Mostra sulla mappa Regione Yorkshire and the Humber East Yorkshire and Northern Lincolnshire Kingston upon Hull, City of Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Steven Haswell (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V. 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