Objective Articulating joint replacements represent a medical market exceeding €14 billion p.a. that is expected to rise as demographics reflect an ageing population. However, faster growth has been seen in the revision market, where prosthetic joints are replaced, than in primary interventions. The major cause of these revisions is that all joint replacements are prone to wear leading to loss of implant function. Further, it has been demonstrated that adverse or extreme loading has a detrimental effect on implant performance. Thus, device failure still occurs too frequently leading to the conclusion that their longevity and reliability must be improved. The premise of this proposal is to realise that wear and corrosion are an inevitable consequence of all implant interfaces within contemporary total joint replacements. To overcome this problem our novel approach is to use silicon nitride coatings in which the combined high wear resistance of this material and solubility of any silicon nitride wear particles released, reduce the overall potential for adverse tissue reactions. In this work a variety of silicon nitride based coatings will be applied to different tribological scenarios related to total hip arthroplasty. The coatings’ suitability in each scenario will be assessed against target profiles. In particular, it is important to consider coating performance within each of these applications under adverse conditions as well as those outlined in internationally utilised standards. To accomplish this, cutting-edge adverse simulation techniques, in vitro assays and animal models will be developed together with a suite of computational assessments to significantly enhance device testing in terms of predicting clinical performance. Data will inform new standards development and enhance current testing scenarios, and will provide 5 European enterprises with a significant market advantage, whilst providing data for a regulatory submission which is aligned with Dir 93/42/EEC. Fields of science engineering and technologymaterials engineeringcoating and filmsnatural scienceschemical sciencesinorganic chemistrymetalloidsmedical and health sciencesmedical biotechnologyimplants Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2012.2.2-1 - Biomaterials for improved performance of medical implants Call for proposal FP7-NMP-2012-LARGE-6 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSITY OF LEEDS EU contribution € 3 256 581,90 Address WOODHOUSE LANE LS2 9JT Leeds United Kingdom See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Higher or Secondary Education Establishments Administrative Contact Karen Anne Steenson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 881 231,60 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Stephen Ferguson (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UPPSALA UNIVERSITET Sweden EU contribution € 1 154 132,00 Address VON KRAEMERS ALLE 4 751 05 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Ylva Bäcklund (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IHI IONBOND AG Switzerland EU contribution € 1 820 427,80 Address INDUSTRIESTRASSE 9 4657 DULLIKEN See on map Region Schweiz/Suisse/Svizzera Espace Mittelland Solothurn Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Kurt Stierli Links Contact the organisation Opens in new window Total cost No data Simulation Solutions Limited United Kingdom EU contribution € 1 244 160,00 Address Rugby Park Bletchley Road Unit 10 SK4 3EJ Heaton Mersey See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nick Eldred (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data University of Zurich Switzerland EU contribution € 601 024,00 Address RAMISTRASSE 71 8006 ZURICH See on map Activity type Higher or Secondary Education Establishments Administrative Contact Brigitte Von Rechenberg (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WILHELM SCHULTHESS STIFTUNG Switzerland EU contribution € 261 300,00 Address LENGGHALDE 2 8008 ZURICH See on map Activity type Other Administrative Contact Nicola A. Maffiuletti (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE LEEDS TEACHING HOSPITALS NATIONAL HEALTH SERVICE TRUST United Kingdom EU contribution € 213 263,20 Address ST JAMES'S UNIVERSITY HOSPITAL, BECKETT STREET LS9 7TF LEEDS See on map Region Yorkshire and the Humber West Yorkshire Leeds Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Anne-Maree Keenan (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AESCULAP AG Germany EU contribution € 197 750,00 Address AM AESCULAP PLATZ 78532 Tuttlingen See on map Region Baden-Württemberg Freiburg Tuttlingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jurgen Winterhalter Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ANYBODY TECHNOLOGY AS Denmark EU contribution € 713 000,00 Address NIELS JERNES VEJ 10 9220 Aalborg See on map Region Danmark Nordjylland Nordjylland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Per Sondrup (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Linköping University Sweden EU contribution € 1 058 579,20 Address CAMPUS VALLA 581 83 Linköping See on map Activity type Higher or Secondary Education Establishments Administrative Contact Pia Heidenberg (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TUTECH INNOVATION GMBH Germany EU contribution € 701 770,00 Address Harburger Schlossstrasse 6-12 21079 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Monica Schofield (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNISCHE UNIVERSITAT HAMBURG Germany EU contribution € 561 212,40 Address AM SCHWARZENBERG CAMPUS 1 21073 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Higher or Secondary Education Establishments Administrative Contact Cordula Elm (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PETER BREHM Germany EU contribution € 479 999,60 Address AM MUHLBERG 30 91085 WEISENDORF See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gerhard Kappelt (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 172 568,30 Address SOUTH KENSINGTON CAMPUS EXHIBITION ROAD SW7 2AZ LONDON See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Shaun Power (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data