Objective
Influenza neuraminidase (NA) is the enzyme that releases influenza virions from the infected cells, cleaving the sialic acid receptor on host cells. It has been recently demonstrated that influenza A has neuraminidase subtypes that belong to two distinct subgroups. The crystal structures of the three subtypes N1, N4 and N8 (group-1 enzymes) were found to be virtually identical in the shapes of their active sites. However they were found to be different when compared to N2 and N9 subtypes (group-2 enzymes). In the case of N1, N4 and N8 subtypes, a loop of amino acids which includes the active site catalytic residue Asp 151, was found to adopt an unusual open conformation compared to the N2 and N9 subtypes in which loop-150 was of a closed conformation. The observation of different active site conformations between certain subtypes of group-1 and group-2 enzymes suggests that these two groups are not only genetically distinct but are also structurally distinct. The main objective of our project is to develop new specific neuraminidase inhibitors with two distinctive important features: 1) a novel general scaffold which provides the correct ring distortion required to mimic both group-1 and group-2 neuraminidase transition-state; 2) further additional groups of suitable shape and size that extend the general structure and fill the cavity-150, with the aim of generate group-1 specific inhibitors. The objectives of the project will be achieved through the employment of multidisciplinary competences, in which the host institutions have enormous experience: design of carbohydrate mimics as inhibitors, libraries synthesis, virus like particles STD-NMR spectroscopy, biological evaluation and molecular modelling.This fellowship will ensure the opportunity for the applicant to be exposed to an international and interdisciplinary context, working on a timely scientific project resulting from the collaboration of two internationally recognized research leaders in glycoscience.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering crystals
- medical and health sciences health sciences infectious diseases RNA viruses influenza
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
20122 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.