Cel In this research program, we propose the new concept that sister chromatid separation in mitosis is completed as a result of the dynamic intrinsic structural changes of chromosomes, i.e. through cycles of regional chromosome stretching and recoiling, which we call the self-clearing mechanism of chromosomes. By developing several novel methods, we will establish this new concept and demonstrate that the self-clearing of chromosomes is an essential mechanism allowing complete removal of sister chromatid cohesion, and that it is a fundamentally conserved function from yeast to vertebrates. To maintain genetic integrity, eukaryotic cells must duplicate their chromosomes and subsequently segregate them to opposite poles of the cell, prior to cell division. Cohesion is established between sister chromatids during S phase and marks sister pairs to ensure proper chromosome segregation in the next mitosis. However, the cohesion must be eventually removed to allow sister chromatids to separate and segregate to opposite poles. Although recent studies have revealed how the removal of cohesion is initiated, it is still elusive how this removal is completed. Our project will address mechanisms promoting this process and will open up a new direction of research, regarding dynamic chromosome organization, in particular its compaction and condensation. At present, the structural basis for chromosome compaction and condensation is poorly understood. Our project will shed new light on this inscrutable scientific problem by revealing the process of chromosome self-clearing. The outcome of our research will give important clues to fundamental mechanisms for chromosome segregation and will contribute to our understanding of human diseases, such as cancer and congenital disorders, which are characterized by chromosome instability and aneuploidy. Dziedzina nauki medical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticschromosomes Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-AG-LS3 - ERC Advanced Grant - Cellular and Developmental Biology Zaproszenie do składania wniosków ERC-2012-ADG_20120314 Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-AG - ERC Advanced Grant Instytucja przyjmująca UNIVERSITY OF DUNDEE Wkład UE € 2 304 081,60 Adres Nethergate DD1 4HN Dundee Zjednoczone Królestwo Zobacz na mapie Region Scotland Eastern Scotland Angus and Dundee City Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Diane Taylor (Ms.) Kierownik naukowy Tomoyuki Tanaka (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko UNIVERSITY OF DUNDEE Zjednoczone Królestwo Wkład UE € 2 304 081,60 Adres Nethergate DD1 4HN Dundee Zobacz na mapie Region Scotland Eastern Scotland Angus and Dundee City Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Diane Taylor (Ms.) Kierownik naukowy Tomoyuki Tanaka (Prof.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych THE UNIVERSITY OF SUSSEX Zjednoczone Królestwo Wkład UE € 186 382,80 Adres SUSSEX HOUSE FALMER BN1 9RH Brighton Zobacz na mapie Region South East (England) Surrey, East and West Sussex Brighton and Hove Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Bettina Lehmbeck (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
