Objective
Cancer is a leading cause of death in Europe. Therefore, improving the efficacy of curative treatments remains a major goal to achieve. Today, with more than 60% of European cancer patients treated with radiotherapy, understanding the biology underlying the cellular response to ionizing radiation (IR) is an ongoing challenge to ameliorate efficacy of this treatment. Basic concepts in tumor radiobiology have evolved. Endothelium irrigating tissues exposed to radiation and signaling events initiated at the plasma membrane are now considered as key issues. Thus, the membrane sphingolipid ceramide, reactive oxygen species (ROS) and importantly p38 MAPK proteins have been identified as critical molecular actors of the membrane initiated-response of the endothelium to IR.
This project aims at characterizing the p38 MAPK pathway in the response of tumor endothelium to oxidative stress/IR and will address the following issues: What are the partners of p38 MAPK (p38-Partns) in IR/oxidative stress/ceramide pathway? Which IR-endothelial dysfunctions are associated with this p38 MAPK/p38-Partns pathway? The outgoing phase will characterize the ceramide/p38 MAPK pathway in endothelial cells exposed to oxidative stress. The methodological approach will rely on mass spectroscopy identification of p38-Partns. Role of p38-Partns in endothelial functions, notably in cell migration and adhesion by supra-resolution TIRF microscopy, will then be investigated. The return phase will explore this p38 MAPK pathway in vitro in endothelium exposed to IR and in vivo in human samples of irradiated tumor microenvironment.
This project will yield new insights in life sciences from fundamental radiobiology and oxidative stress biology to identification of potential new targets for improvement of radiotherapeutical benefit.
This proposal will provide scientific expertise and additional training (people management, ethics, translational research) that will impact the fellow’s career development
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences nuclear physics
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine oncology
- natural sciences physical sciences optics spectroscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.