Objective
"The Daphniphyllum alkaloids are a huge family of architecturally complex natural products found in evergreen trees and shrubs native to south-east Asia. To date, more than 200 members have been isolated and structurally characterised; some of them have been shown to possess interesting biological activity, such as cytotoxic- or antioxidative properties. However, not least due to their limited availability – both from natural sources and via chemical total syntheses – the biological functions and pharmacological properties of Daphniphyllum alkaloids have been only poorly studied until now. From an organic chemist`s point of view, members of the Daphniphyllum - family present highly attractive targets for synthetic approaches. Apart from their potential use as drugs or drug candidates, their fascinating, polycyclic skeletons present a vast playground to elaborate innovative synthetic strategies and tactics. Daphlongeranine B was isolated from the fruits of Daphniphyllum longeracemosum in 2007 and was shown to exhibit in vitro platelet aggregation. Its unprecedented hexacyclic core with seven stereogenic centres, three of which are fully substituted, presents a formidable and as yet unmet synthetic challenge. We are proposing the first total synthesis of Daphlongeranine B taking advantage of a series of partly unprecedented, powerful catalyst- and substrate controlled reactions and also cascade sequences. Their application will allow us to construct the target molecule in a nineteen-step route, starting from simple starting materials. Our proposed synthetic strategy features a novel tandem aminomethylation-alkynylation sequence, an unprecedented gold-catalysed 5-endo-dig hydroamination, a diastereoselective epoxidation followed by semipinacol rearrangement and a highly diastereoselective Michael-addition / Pd (0) catalysed vinylation cascade."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- agricultural sciences agriculture, forestry, and fisheries agriculture horticulture fruit growing
- natural sciences chemical sciences catalysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.