Objective
Malaria continues to be the most important parasitic disease with as many as one million deaths annually. Despite these sobering figures, there is a decline in the burden of malaria that has stimulated researchers to set an agenda for worldwide malaria eradication. Malaria transmission blocking vaccines (MTBV) that induce antibody responses that prevent the transmission of malaria from man to mosquito are high on the priority of this research agenda. However, the number of MTBV candidates has remained practically unaltered in the last 20 years and none have successfully entered clinical trials. This proposal aims to provide a leap forward in the identification of novel MTBV target antigens and unravelling the immune signature of naturally acquired transmission blocking immunity (TBI).
For this purpose, samples will be used that have been collected in large-scale epidemiological studies, where they were included in mosquito feeding assays in the field to confirm their transmission potential. TBI will be confirmed by adding purified IgG to cultured gametocytes in the highly standardized standard membrane feeding assay (SMFA) at the Nijmegen Centre for Molecular Life Sciences of the Radboud University, Nijmegen. Functional TBI will be quantified as the reduction in the proportion of infected mosquitoes compared to malaria naïve control IgG. Samples with and without evidence for TBI will be matched for cumulative malaria exposure and used for immune profiling using a recently developed protein microarray. This protein microarray contains >20% of the P. falciparum 5,400-protein proteome and more than 300 uncharacterized sexual stage specific proteins that may be involved in TBI. By combining novel immunological, entomological and molecular tools, our approach will plausibly identify novel targets for TBI and lead to new horizons for MTBV development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences infectious diseases malaria
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- natural sciences biological sciences zoology invertebrate zoology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.