Obiettivo "It is now increasingly clear that most of our genome is transcribed, but that only a small portion is associated with protein coding gene. Indeed, recent analysis indicate that long non-coding RNA outnumbered by five fold the coding RNA sequences. Despite this abundance, very little is known on the function of these long non-coding RNA.The aim of this proposal is to understand the function of pathological long non-coding RNA. We will first focus our studies on the RNA gain-of-function diseases. These genetic diseases are caused by the pathogenic expansion of nucleotide repeats, which are transcribed into long non-coding RNA that titrate and sequester specific RNA-binding proteins, leading to molecular changes ultimately resulting in the symptoms of these pathologies. The RNA gain-of-function diseases include the most common muscular dystrophies in adult: the Myotonic Dystrophies of type 1 and type 2 (DM), the common neurodegenerative Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) and the rare, but deleterious, Spinocerebellar Ataxia 10, 31 and 36 (SCA10, SCA31 and SC36).We propose to :1 – Identify the proteins sequestered by theses expanded RNA repeats.2 – Identify the molecular causes of DM, FXTAS and SCA diseases in iPS neuronal cell model and mouse models.3 – Identify pharmacological compounds able to reverse the toxic effects of these RNA.Importantly, these RNA gain of function diseases present identical symptoms to other pathologies that are much more common and tremendously challenging to our society (for example the tremor in FXTAS is similar to the one observed in Parkinson; the cognitive impairment, the demence and the neurodegeneration found in FXTAS are present in Alzheimer Disease; the heart failure, which is a leading cause of morbidity in Europe is a cardinal symptom of DM; etc.).THUS, ELUCIDATING THE MOLECULAR CAUSES OF THESE RNA DISEASES MAY HELP TO UNDERSTAND THE PATHOLOGY OF OTHER COMMON AND CHALLENGING DISEASES." Campo scientifico medical and health sciencesbasic medicineneurologymuscular dystrophiesnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesgeneticsRNAmedical and health sciencesclinical medicinecardiology Programma(i) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) ERC-SG-LS1 - ERC Starting Grant - Molecular and Structural Biology and Biochemistry Invito a presentare proposte ERC-2012-StG_20111109 Vedi altri progetti per questo bando Meccanismo di finanziamento ERC-SG - ERC Starting Grant Istituzione ospitante CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Contributo UE € 1 499 920,00 Indirizzo Rue Laurent Fries 1 67404 Illkirch Graffenstaden Francia Mostra sulla mappa Regione Grand Est Alsace Bas-Rhin Tipo di attività Research Organisations Ricercatore principale Nicolas Charlet Berguerand (Dr.) Contatto amministrativo Steve Brooks (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Beneficiari (1) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE Francia Contributo UE € 1 499 920,00 Indirizzo Rue Laurent Fries 1 67404 Illkirch Graffenstaden Mostra sulla mappa Regione Grand Est Alsace Bas-Rhin Tipo di attività Research Organisations Ricercatore principale Nicolas Charlet Berguerand (Dr.) Contatto amministrativo Steve Brooks (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato