Objective
NanoQuench project is about the development of alternative methods to coat indewelling medical devices to control microbial biofilms with relevance to clinical drug resistance. Biofilms are bacterial communities embedded in a self-produced polymeric matrix that commonly grow on indwelling medical devices, such as catheters. This mode of growing is believed to be regulated by a quorum-sensing (QS) system, a unique mechanism of communication that bacterial cells use through the secretion and uptake of small hormone-like molecules, called autoinducers. Due to their innate resistance to the immune system and low susceptibility to antibiotics, the microbial biofilms are difficult to treat and are a major factor in the morbidity and mortality of most infectious diseases. Methods by which the initial stages of bacterial attachment and biofilm formation can be restricted or prevented are therefore needed. Technologies that avoid catheter biofilm formation are based mainly on the application of conventional antimicrobial agents. However, the high resistance of bacteria within the biofilm makes any single therapeutic intervention unlikely to have sufficient effect.
This project focuses on the development of an integrated technological platform comprising quorum quenching enzymes and novel antibacterial agents (nanoantibiotics), able to counteract biofilm formation and at the same time avoid development of bacterial resistance to the therapy. These functional compounds will be coated onto catheters via layer-by-layer technique or a novel ultrasonic process.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08034 BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.