Cel The control of genome duplication is critical for proper cell growth and proliferation. Errors in DNA synthesis and defects in genome maintenance have been linked to many human diseases such as cancer. In eukaryotes, replication initiates at sites located throughout the genome called origins, whose activation and distribution define the program of DNA replication. However, while changes in this pattern of replication have been observed in Xenopus and Drosophila during development, in differentiating mouse and human cells, and in a number of cancers, it remains unknown whether undergoing S phase with particular programs of origin selection has actual consequences on cellular function. Using the fission yeast Schizosaccharomyces pombe, an excellent model for studying cell cycle progression and DNA replication, we have investigated the impact of modifying origin usage on the process of meiosis. Our work indicates that origin selection is a major determinant for organizing meiotic recombination, providing the first evidence for functional consequences of genome-wide changes in the replication program. Taking advantage of the system that we have established, we propose to study the links between these two fundamental processes at both the population and single cell levels, focusing on the mechanisms that coordinate origin activity with the exchange of genetic material through meiotic recombination. Dziedzina nauki natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologynatural sciencesbiological sciencesgeneticshereditynatural sciencesbiological sciencesgeneticsgenomes Program(-y) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Zaproszenie do składania wniosków FP7-PEOPLE-2012-CIG Zobacz inne projekty w ramach tego zaproszenia System finansowania MC-CIG - Support for training and career development of researcher (CIG) Koordynator CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Wkład UE € 100 000,00 Adres RUE MICHEL ANGE 3 75794 Paris Francja Zobacz na mapie Region Ile-de-France Ile-de-France Paris Rodzaj działalności Research Organisations Kontakt administracyjny Emmanuelle Malesys (Mrs.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
