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Content archived on 2024-05-30

Metabolic engineering of triterpenoid pathways involved in plant defense in Arabidopsis and rice

Objective

"Plants produce a diversity array of natural products (otherwise known as secondary metabolites) that have important ecological functions (Dixon 2001; Field and Osbourn 2008). Triterpenes are one of the largest classes of plant-derived natural products. These compounds protect plants against pests and diseases and are also important as drugs and anticancer agents (Papadopoulou et al 1999; Phillips et al 2006; Liby et al 2007). Arabidopsis and also cereals such as rice do not make protective triterpene glycosides (Hostettmann & Marston, 1995; Vincken et al 2007). These model species are therefore excellent experimental systems for proof-of-concept experiments involving metabolic engineering of triterpene pathways into heterologous species. The aim of this proposal is to engineer triterpene metabolic pathways into Arabidopsis and rice by genetic modification. As part of this work I will develop methods for introducing multiple genes into plants using recombineering and synthetic biology approaches. At the end of this project we will have the necessary knowledge to devise strategies to introduce multiple genes into diverse plant species for control of plant pests and diseases based on synthesis of protective triterpenes."

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2012-IEF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

JOHN INNES CENTRE
EU contribution
€ 221 606,40
Address
NORWICH RESEARCH PARK COLNEY
NR4 7UH Norwich
United Kingdom

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Region
East of England East Anglia Breckland and South Norfolk
Activity type
Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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