VICQUATProject reference: 329876
Funded under :
Methodology for and Synthesis of Highly Congested Molecules
Total cost:EUR 221 606,4
EU contribution:EUR 221 606,4
Coordinated in:United Kingdom
Topic(s):FP7-PEOPLE-2012-IEF - Marie-Curie Action: "Intra-European fellowships for career development"
Call for proposal:FP7-PEOPLE-2012-IEFSee other projects for this call
Funding scheme:MC-IEF - Intra-European Fellowships (IEF)
The development of new methodologies which allow for the direct synthesis of highly complex molecular entities bearing vicinal all carbon quaternary stereocentres remains a most important goal for modern synthetic chemists.
The aim of this proposal is to develop cutting-edge methodology for congested molecule synthesis and apply it to the total synthesis of the core of a highly complex natural product.
Phase 1 of the project will involve the development of three related methodologies which will allow for the efficient synthesis of a wide range of highly complex tricyclic molecules bearing multiple stereocentres including vicinal all carbon quaternary stereocentres from simple achiral starting materials.
In Phase 2 of the project the developed methodologies will be used to synthesise the complex tetracyclic core of a highly complex biologically active terpenoid natural product. The tetracyclic core will be further functionalised using state-of-the-art synthetic transformations.
EU contribution: EUR 221 606,4
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