The role of long intergenic non-coding RNA in intestina stem cells

Projektinformationen

LincRNA

ID Finanzhilfevereinbarung: 330571

Abgeschlossenes Projekt

Startdatum 1 März 2013

Enddatum 28 Februar 2015

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 183 469,80

EU-Beitrag € 183 469,80

Koordiniert durch

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Netherlands

Ziel

Studies on long intergenic non-coding RNAs (lincRNAs) suggest an important role in development and cancer, however, functional lincRNAs in adult stem cells have been rarely defined. This project will study the role of lincRNAs in development of intestinal stem cell (ISC) one of the well identified adult stem cells. For this purpose, I will identify lincRNAs that are specifically expressed in ISCs by analyzing transcriptome of sorted ISCs. LincRNAs expected to regulate ISC development will be selected. I will investigate the mechanisms of action of the lincRNAs using in vitro cultured mini-gut. Lastly, I will elucidate the physiological function of the lincRNAs by generating knock-out mouse models.
It has become evident that lincRNAs regulate multiple cellular functions including pluripotency, differentiation, and cell cycle. This project will, therefore, broaden our knowledge on adult stem cell biology revealing how lincRNAs play a role in self-renewal and differentiation of ISCs. At the same time, this project will extend our understanding of lincRNA biology by providing a comprehensive functional study in a physiologically relevant system. Furthermore, given that ISCs are highly linked with cancer stem cells, the defined lincRNAs might be used as diagnostic markers and therapeutic targets in cancer.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › cell biology
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › oncology
• natural sciences › biological sciences › genetics › RNA

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-2012-IIF - Marie Curie Action: "International Incoming Fellowships"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-2012-IIF
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IIF - International Incoming Fellowships (IIF)

Koordinator

KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW

Kontakt Verwaltung

Don Van Velzen (Mr.)

• EU-Beitrag: € 183 469,80
• Adresse: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS ; 1011 JV AMSTERDAM ; Niederlande
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Aktivitätstyp: Research Organisations
• Gesamtkosten: Keine Daten