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Content archived on 2024-06-18

Brain connectomics: modeling disconnection syndrome in Multiple Sclerosis

Objective

Brain architecture or connectivity is complex and defines the basis of cognitive processing. Recent studies have revealed new insights about its organization by the combination of structural Magnetic Resonance Imaging (MRI) such as tractography (using Diffusion Spectrum Imaging, DSI) and functional MRI (fMRI) using resting-state. However, the complexity of brain connectivity and technical limitations prevent a comprehensive understanding of its organization. For this reason, the use of disease models producing disconnection syndromes, such as Multiple Sclerosis (MS) are important approaches for improving our understanding about brain organization. Moreover, MRI analysis of MS by DSI and fMRI can provide new insights on MS pathogenesis and development of new biomarkers of the disease, helping to solve the “clinical-MRI paradox”, namely the low correlation between MRI findings and clinical course.
In this proposal we present new models for studying brain connectivity by analyzing MS. We intend to use state-of-the-art approaches in brain connectomics and apply inter-disciplinary techniques ranging form different MRI modalities to network analysis and image processing techniques. The candidate has a strong technical background and a PhD in a very related area - the technical aspects of the imaging techniques. The host group is strong in applied clinical research, with focus on MS, imaging, cognitive sciences and systems neurosciences. The host group has several ongoing collaborations with top researchers in cognitive neuroscience and connectomics. Finally, the findings and techniques that will be developed in this project can be transferable to clinical practice but also with minor modifications applied to similar neurological diseases and the research involving general questions on how the brain functions.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2012-IEF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IEF - Intra-European Fellowships (IEF)

Coordinator

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
EU contribution
€ 173 370,60
Address
CALLE ROSSELLO 149 PUERTA BJS
08036 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Other
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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