Objective
It has been established that the epigenetic landscape (cytosine methylation, histone modification and non coding RNAs) impacts on the underlying genomic architecture thereby regulating the transcriptional machinery and modifying gene expression. These elegant mechanisms of control influence tissue differentiation, organism life spam and can coordinate biochemical pathways responses to stressors such as UV light and elevated metal ion concentrations. It is the aim of this project to test the overarching hypothesis that:
“Alterations in the epigenetic landscape caused by exposure to environmental contaminants directly modulate the expression of specific genes increasing phenotypic plasticity and providing the mechanistic basis underpinning the organism’s responses to the stress inducing causative stimuli.”
We will test this hypothesis using, the epigeic earthworm L. rubellus, establishing it as a model to study the interactions between the environment and the epigenome.
The experiment plan is designed to derive a causative relationship between modifications in the epigenome and the ability of an organism to tolerate specific environmental challenges. The project will primarily exploit metals/metalloids (Ni & As) with a mechanism-of-action with postulated impact on the epigenome, but the wider aim is to establish a new paradigm between the epigenetic landscape and the environment.
The training programme will put great emphasis on exploring the opportunities provided by next generation sequencing technologies and the rich genomic resource provided by our target organism. This will require training in the technical, bioinformatics and informative frame works that will enable the production of a refined physical map of the earthworm epigenomic landscape. The training will exploit an established network of national and international partnerships with the primary goal of establishing the proposed fellow as a research leader in their own right.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics RNA
- natural sciences chemical sciences inorganic chemistry metalloids
- natural sciences biological sciences genetics genomes
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CF10 3AT CARDIFF
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.