Objetivo Protein filaments and their geometrical organization are crucial for cell mechanics, and their failure is related to diseases ranging from sickle cell anemia to Alzheimer’s to cancer. While such stakes would suggest a well-defined design to the engineer, sub-cellular filamentous structures are often surprisingly disordered, and very variable from one cell to the next. Physically, this disorder can be traced back to complicated random aggregation processes involving particles with intricate structures far from equilibrium. To help understand this paradoxical combination of reliability and randomness in the cell’s architecture, I plan on theoretically characterizing robust, generic organizational principles for biofilaments on multiple, interrelated scales, from the whole cell to individual proteins.I will first consider disordered assemblies of actin filaments and molecular motors that contract in vivo. These systems self-organize to induce cell motility according to different mechanisms than ordered structures, and I will ask which of these non-conventional mechanisms dominates their activity. This problem crucially involves the mesoscopic structure of the filament assembly, which I will consider next. Going beyond existing naive equilibrium models, this second study will focus on the out-of-equilibrium competition between filament growth and aggregation, which experiments have recently shown to dominate actin gel structure. Finally, I will question the foundations of these two first studies by asking why protein filaments are so abundant; indeed, they form even in situations where their presence harms the cell. To this end, I will show that irregular protein-like particles have a natural tendency towards filament formation, which relieves the geometrical frustration resulting from their ill-fitting shapes. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologymedical and health sciencesclinical medicinehematology Programa(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Convocatoria de propuestas FP7-PEOPLE-2012-CIG Consulte otros proyectos de esta convocatoria Régimen de financiación MC-CIG - Support for training and career development of researcher (CIG) Coordinador CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Aportación de la UE € 100 000,00 Dirección RUE MICHEL ANGE 3 75794 Paris Francia Ver en el mapa Región Ile-de-France Ile-de-France Paris Tipo de actividad Research Organisations Contacto administrativo Véronique Debisschop (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos
