Objective
Cardiovascular disease (CDV) is a serious health issue and one of the main causes of death in developed countries. The connection between lipids and the disease progress has been established in the past years. Particularly, lipid composition in blood circulating lipoproteins may have a significant correlation with CVD and CVD risk. However, although in the past years lipidomics-based platforms have been developed and mainly focused on the lipid profiling in blood in diverse studies, little attention has been drawn so far to their study according to lipoprotein fractions, which is essential. In this project, the development of an integrated analytical platform will be tackled for the separation of lipoproteins from plasma samples, extraction of lipids in the protein fractions and lipid profiling. Lipoprotein separations by capillary electrophoresis will be coupled on-line to liquid-liquid extraction of lipids and further LC-MS/MS, to constitute the first integrated platform for this type of analysis. The implementation of the platform in a lab-on-a-chip system will be explored for achieving fast, automated, low sample requirement, high-throughput analyses. This will open-up a wide range of analytical possibilities and new insights in the lipid biochemistry in cardiovascular disease. The methodology will be applied for the analysis of plasma blood samples from healthy volunteers and individuals with different degrees of CVD for disease biomarker discovery. Finally, the analysis of samples from tracer-based studies in dynamic systems in mouse models will also be possible. In addition, this will allow studying the effect on drugs on lipid biochemistry, and to fine-tune exciting therapies or to develop new treatment options in CVD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- engineering and technology other engineering and technologies microtechnology lab on a chip
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- natural sciences chemical sciences electrochemistry electrophoresis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2311 EZ Leiden
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.