Obiettivo "Specific interactions between drugs and biomolecules are fundamental to many biological processes. It is well known that biomolecules can undergo extensive changes upon irradiation in the presence of drugs, which can behave as photosensitizers leading to adverse side-effects (e. g., to a loss of their biological function). Thus, protein-protein photocrosslinking, or drug-protein photobinding originating photoallergy, as well as DNA damage resulting in photomutagenicity and photogenotoxicity, are well known. Clearly, a precise knowledge of the active sites where drugs can interact with biomolecules and the involved reaction mechanisms would contribute to understanding the photosensitizing potential of new drug candidates. To address this issue, photophysical techniques (fluorescence and transient absorption techniques, from the femtosecond to the nanosecond time scales) will be used in order to get insight into the mechanisms involved in drug-DNA or drug-protein interactions as well as to improve the knowledge in the photochemical reaction pathways that can provoke damage to the biomolecule. To this end, model systems, whose complexity will be progressively increased, that simulate the real drug-biomolecule interactions, will be designed in order to study their photophysical properties and photochemical reactivity. Investigation on the mechanistic pathways leading to photodamage may thus contribute to the design of new therapeutic agents inducing less adverse side effects to the organism, which may have applications in pharmaceutical and skin photoprotection industries." Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesgeneticsDNAnatural sciencesbiological sciencesbiochemistrybiomoleculesnatural scienceschemical sciencesphysical chemistryphotochemistry Programma(i) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Argomento(i) FP7-PEOPLE-2012-CIG - Marie-Curie Action: "Career Integration Grants" Invito a presentare proposte FP7-PEOPLE-2012-CIG Vedi altri progetti per questo bando Meccanismo di finanziamento MC-CIG - Support for training and career development of researcher (CIG) Coordinatore UNIVERSITAT POLITECNICA DE VALENCIA Contributo UE € 50 000,00 Indirizzo CAMINO DE VERA SN EDIFICIO 3A 46022 Valencia Spagna Mostra sulla mappa Regione Este Comunitat Valenciana Valencia/València Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Andres Moratal Rosello (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
