Objective
Obesity is one of the greatest public health challenges of the 21st century. Affecting over half a billion people worldwide, it increases the risk of stroke, ischaemic heart disease, diabetes, many cancers, depression and complications in pregnancy. Bariatric surgery is currently the only effective treatment available but is associated with significant risks of mortality and long-term complications. New and innovative treatments are thus required.
The signals to and from the gut during eating and digestion are passed through the vagus nerve. Despite this, our knowledge of vagus nerve function comes from studies in which the nerve is cut. This fails to provide any impression of the complex signal received by appetite centres in the brain.
We propose to use obesity as a paradigm for development of a new generation of neural interface that will combine novel electrode materials, structures and sensing modalities with ultra-low power electronic neural recording, analysis, stimulation and wireless communication. Several steps beyond state-of-the-art, this will allow, for the first time, detailed study of the entirety of vagus nerve function. We will develop neural stimulation that mimics the response of the vagus nerve to ingestion of food, thus providing a new treatment for obesity.
The synergy between our groups will thus combine complementary interests to develop an innovative technological solution for a major public health crisis. The sensing capability will deliver, for the first time, real-time and long-term recordings, providing new insights into peripheral nerve activity. The impact will thus extend beyond appetite and the vagus to many other neurally regulated processes and diseases.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine obstetrics
- medical and health sciences basic medicine neurology stroke
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-SyG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.