Objective
A key feature of the immune response is its specificity and macrophages must be able to discriminate precisely between an infectious stimulus and a non-infectious one and tune their response in accordance with the molecular context in which the target particle is recognized. In recent years, scientists have proposed the concept of the phagocytic synapse, to stress the fact that a particle does not engage only one receptor on the cell surface; instead, an array of receptors interacts with a specific pathogen, either sequentially or simultaneously. Indeed, the tightly controlled and specific responses of macrophages require the establishing of checkpoints for signalling and the phagocytic synapse represent an exquisite site for cross-talk among several signalling pathways. Although we can describe detailed signalling pathways for most of the single receptors acting at the phagocytic synapse, we still do not know how these pathways are integrated during the various phases of macrophage responses. An integrated view of phagocytic synapse signalling would allow us to understand the contribution of each ligand-receptor pair to macrophage dysfunctions in pathology and to design novel immunotherapeutic strategies.
The aim of STePS is to provide a deeper understanding of the molecular interactions leading to the orchestration of phagocytic synapses for phagocytosis and activation, two events crucial for immune responses to pathogens as well as for inflammation. In particular, we will focus on three fundamental aspects that bring together the fields of immunology and cell biology: establishment of dynamic platforms for recognition and signalling at the plasma membrane; vesicle trafficking to the plasma membrane; signalling compartmentalization for specific cell functions. Importantly, these mechanisms will be analyzed in the context of physiological and pathological conditions, thus providing answers to both basic and translational biomedical research questions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences cell biology
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-ADG_20120314
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
35122 PADOVA
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.